Disorders of phosphate metabolism.

Correct identification of the disorders of hypophosphatemia and hyperphosphatemia is important for determining therapy. Further research will provide insights into normal phosphate homeostasis, a complex and fascinating process.

Disorders of puberty: inactivating and activating molecular mutations.

Recent developments have increased our understanding of the molecular mechanisms that are responsible for several disorders of puberty. Specific gene mutations have been identified in three syndromes, one that is associated with delayed puberty (Kallmann syndrome) and two that are associated with precocious puberty (McCune-Albright syndrome and familial male precocious puberty). Mutations in the KAL gene have been shown to be responsible for cases of X-linked Kallmann syndrome.

Paclitaxel stability and compatibility in polyolefin containers.

Objective: To determine the compatibility and stability of paclitaxel in polyolefin containers.

Design: The following paclitaxel concentrations were determined by a stability-indicating HPLC method: 0.3 and 1.

[An epidemiologic study of the orodental status of 6-15-year-old children in the Languedoc-Roussillon region].

An epidemiological study of a representative sample of 702 children, aged 6 to 15 years, was conducted in the Languedoc-Roussillon region composed of the departments of Aude, Gard, Hérault, Lozère and Pyrénées Orientales. The mean DMFT at 12 years of 4.21 was always higher in girls (5.