Interleukin 8 Is Overexpressed in Acute Rejection in Kidney Transplant Patients.

The main complication associated with renal graft loss is immune rejection. The gold standard for the diagnosis of renal graft rejection is percutaneous renal biopsy, which is expensive and can lead to complications. Inflammation is one of the main pathogenic pathways in allograft rejection, and urine samples seem to be efficient windows to explore the allograft condition with a high cost-benefit ratio.

Cardiac Remodeling in Structure and Function Six Months After Kidney Transplantation.

Background: Cardiovascular disease accounts for 35% to 50% of the causes of mortality in chronic kidney disease. The majority of patients in substitution therapy in Mexico are subdialyzed owing to limited economic resources. This produces more cardiac deterioration than described in the statistics and has a direct impact on the prognosis of kidney transplantation.

Correlation of the Glomerular Filtration Rate Measured With the Use of DTPA-Tc99m in Live Kidney Donors With Equations Based on Creatinine and Cystatin C.

Background: Renal donation leads to a risk of developing chronic kidney disease, with an incidence of 0.47%. To evaluate for its presence, formulas based on serum creatinine are used, but up to 80% of these formulas underestimate the glomerular filtration rate (GFR) in donors.

Lack of Association Between Elevated Urinary Levels of Interleukin-10 and Interferon Gamma With the Presence of Inflammation in Kidney Transplant Recipients.

Introduction: A lot of evidence has demonstrated the importance of different cytokines in acute renal rejection. Previous studies have examined the presence or absence of interleukin (IL)-10 in related immunopathologic rejection grafts as well as other interleukins. Studies in human transplantation show elevated levels of IL-10 and gamma interferon (INF-γ) in inflammation and rejection.

Reproducible model to perform kidney transplantation in a low-resource population.

Background: In several countries, organ transplantation is limited. We describe the implementation of a model to perform kidney transplantation in a low-resource population through a financial mechanism sharing public, patient, and private foundations funds.

Methods: This was a cohort study of 100 low-resource patients undergoing renal transplantation at the Hospital General of México.

Disseminated encephalitozoon cuniculi infection in a Mexican kidney transplant recipient.

Background: No cases of Encephalitozoon cuniculi infection have been reported in transplant patients.

Methods: A 42-year-old man received a renal transplant 8 months earlier because of terminal glomerulonephritis and was admitted with cough, fever, diarrhea, abdominal pain, and colon wall thickening. While under rapamycin (2 g/day), cyclosporine A (4.

[Effectiveness of preemptive therapy with ganciclovir in recipients of renal transplants at high risk (R-/D+) for the development of cytomegalovirus disease].

Current management of renal transplant recipients who are CMV seronegative (R-) and receive an organ from a seropositive donor (D+) is controversial. These patients are at high risk for CMV disease and are usually treated with ganciclovir prophylaxis at variable dose and duration. An alternative to this approach is to administer ganciclovir only to those patients who are identified by virological markers to be at the highest risk to develop the disease (preemptive therapy).

Primary immunosuppression with tacrolimus in renal transplantation: a multicenter, open-label study.

A multicenter, prospective, open-label trial was performed to assess the efficacy and safety of tacrolimus for primary immunosuppression in renal transplantation. Twenty patients were evaluated after receiving cadaveric and living, related or unrelated kidney transplants and were monitored for 6 months for patient and graft survival, incidence of acute rejection, and incidence of adverse events. Tacrolimus at a final mean dose of 0.

[Retrorectal tumors].

Objectives: To analyze the clinical presentation, and diagnostic and therapeutic implications in patients with retro-rectal tumors.

Methods: This paper reports two patients. Both patients had constipation and change in bowel habits, and the physical examination revealed the retro-rectal neoplasia.