Publications by authors named "Dilip Koshy"

Article Synopsis
  • Many liver transplantation programs no longer require a set period of abstinence for candidates, but effective monitoring for ongoing alcohol use is necessary.
  • Urinary ethyl glucuronide (EtG) testing is highlighted as an objective measure to detect alcohol consumption in patients with alcohol-associated liver disease (ALD) during the pretransplant phase.
  • In a study of 497 ALD patients, only 8% tested positive for EtG, with severe alcohol use disorder, lower daily consumption, and prolonged substance use being significant factors linked to positive results; psychiatric issues were not strongly related.
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Since 2018, our program has utilized specific psychosocial criteria and a multidisciplinary approach to assess patients for liver transplant due to alcohol-associated liver disease (ALD), rather than the 6-month abstinence rule alone. If declined based on these criteria, specific recommendations are provided to patients and their providers regarding goals for re-referral to increase the potential for future transplant candidacy. Recommendations include engagement in treatment for alcohol use disorder, serial negative biomarker testing, and maintenance of abstinence from alcohol.

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OBJECTIVE The efficacy of endoscopic third ventriculostomy (ETV) for the treatment of pediatric hydrocephalus has been extensively reported in the literature. However, ETV-related long-term outcome data are lacking for the adult hydrocephalus population. The objective of the present study was to assess the role of ETV as a primary or secondary treatment for hydrocephalus in adults.

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Perineuronal satellite cells have an intimate anatomical relationship with sensory neurons that suggests close functional collaboration and mutual support. We examined several facets of this relationship in adult sensory dorsal root ganglia (DRG). Collaboration included the support of process outgrowth by clustering of satellite cells, induction of distal branching behavior by soma signaling, the capacity of satellite cells to respond to distal axon injury of its neighboring neurons, and evidence of direct neuron-satellite cell exchange.

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