Publications by authors named "Dilip Gole"
Reconstituted parenteral solutions of three surface-active anti-infective small-molecule drugs and solutions of sodium dodecyl sulfate (SDS, a model surfactant) were studied to quantify the impact of sample preparation and handling on particle counts. Turbidimetry and light obscuration profiles were recorded as a function of agitation and shearing with and without the introduction of foam into the solutions. SDS solutions at concentrations above the critical micelle concentration (CMC) show significantly greater sensitivity to shear and foam presence than SDS solution below the CMC: Values of >10 μm particles increased 8 fold over control (an unsheared sample) in the micellar solution vs.
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- The study examined how well the new cephalosporin drug, ceftobiprole medocaril, mixed with 70 other medications during Y-site injection.
- Ceftobiprole was tested in three different solutions (5% dextrose, 0.9% sodium chloride, and lactated Ringer's) and was found to be compatible with 31 drugs while being incompatible with 32, with 7 showing variable compatibility based on the solution used.
- It was concluded that ceftobiprole should not be given at the same time as incompatible drugs to avoid potential issues like visible particles and turbidity in the mixture.