Publications by authors named "Dilihumaer Aili"
Pan-cancer analysis identifies the oncogenic role of in human cancers.
Aging (Albany NY)
November 2024
Objective: To investigate expression, prognosis, immune cell infiltration of C () in cancer.
Methods: We used TIMER and GEPIA datasets to analyze the differential expression of in multiple tumors. GEPIA and Kaplan-Meier plotter databases were utilized to observe the prognostic significance of in cancer.
Previous study indicated that CHK1 was important for repairing DNA damage and cell cycle regulation. To investigate the association of Checkpoint kinase 1 (CHK1) expression with clinicopathological features, prognosis, and immune infiltration in cancer. Several databases were searched for relevant publications to conduct a meta-analysis to reveal the association between CHK1 and clinicopathological features of cancer.
View Article and Find Full Text PDFTendon and ligament injuries account for a substantial proportion of disorders in the musculoskeletal system. While non-operative and operative treatment strategies have advanced, the restoration of native tendon and ligament structures after injury is still challenging due to its innate limited regenerative ability. Cell sheet technology is an innovative tool for tissue fabrication and cell transplantation in regenerative medicine.
View Article and Find Full Text PDFBackground: Although previous studies have shown an association between clinically used antibiotics and type 2 diabetes, the relationship between antibiotic exposure from food and drinking water and type 2 diabetes in middle-aged and older adults is unclear.
Objective: This study was aimed at exploring the relationship between antibiotic exposures from different sources and type 2 diabetes in middle-aged and older people, through urinary antibiotic biomonitoring.
Methods: A total of 525 adults who were 45-75 years of age were recruited from Xinjiang in 2019.
Article Synopsis
- Von Willebrand factor (VWF) plays a crucial role in coronary artery disease by linking platelets to damaged blood vessels, and this study aimed to determine if VWF antigen (VWF: Ag) levels could predict clinical outcomes after acute myocardial infarction (AMI).
- The study involved 374 participants, including 209 with AMI, monitoring their plasma VWF: Ag levels post-coronary angiography over two years, focusing on major adverse cardiopulmonary and cerebrovascular events (MACEs).
- Results showed that AMI patients had significantly higher VWF: Ag levels than controls, and those with elevated levels were more likely to experience long-term MACEs, indicating VWF: Ag levels could serve as independent
The Xinjiang autonomous region, located in west China, has a unique ethnic structure and a well-developed livestock industry. People in this region have a high risk of exposure to antibiotics, but the exposure level to antibiotics in relation to dietary determinants is unknown. In this study, 18 antibiotics, including four human antibiotics (HAs), four veterinary antibiotics (VAs), and 10 preferred veterinary antibiotics (PVAs) were detected in the urine of approximately half of the 873 adults in Xinjiang, including Han Chinese (24.
View Article and Find Full Text PDFBackground: Waist circumference (WC), visceral adiposity index (VAI), lipid accumulation product (LAP), and Chinese visceral adiposity index (CVAI) are considered surrogate indicators of abdominal fat deposition, but the longitudinal association of these indices with cardiovascular (CV) events in adults with type 2 diabetes (T2D) remains unclear. Our study aimed to examine the associations between abdominal obesity indices and incident CV events among people with T2D and to compare their predictive performance in risk assessment.
Methods: The present study included 2328 individuals with T2D from the Xinjiang Multi-Ethnic Cohort.
Numerous studies have reported the critical roles of long non-coding RNAs (lncRNAs) in the regulation of osteoarthritis (OA) development. The present study aimed to assess the function and regulatory mechanism of a lncRNA, KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), in OA . C28/I2 cells were treated with lipopolysaccharide (LPS) to generate an OA model.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates the effectiveness and safety of lutikizumab against traditional osteoarthritis treatments like NSAIDs, duloxetine, and tramadol, which have limitations due to tolerability and safety issues.
- The analysis included data from 24 studies and found that while duloxetine was the best for pain relief, lutikizumab did not significantly improve pain or function compared to placebo.
- Overall, selective cox-2 inhibitors and duloxetine were confirmed as the most effective treatments, indicating the need for further high-quality research on lutikizumab.