Roles of Single Nucleotide Polymorphisms of Gene in Patients with Coronary Artery Disease.

Background: This study aims to investigate the association between nine tag single nucleotide polymorphisms (SNPs) in the gene locus and the risk of coronary artery disease (CAD) as well as lipid levels in the Chinese population, and to further explore the interactions between SNPs and environmental factors that may be associated with CAD risk.

Methods: A case-control study was conducted to investigate the association between CAD and gene polymorphisms in a hospital setting. The study consisted of 944 CAD patients with a mean age of 55.

Nomogram developed with genetic variant rs662799 and clinical characteristics predicting risk of essential hypertension in a Chinese population.

Background: The apolipoprotein A5 () gene has been identified as a key regulatory factor in triglyceride (TG) metabolism and plasma lipid levels. Genetic polymorphisms of have been linked to an elevated risk of atherosclerosis, metabolic syndrome, stroke, and coronary artery disease. The rs662799 variant is a single nucleotide polymorphism (SNP) that occurs at a specific position within the gene.

FOXO3a functions as a transcriptional and co-transcriptional splicing regulator in vascular endothelial cell lines.

Recent studies have indicated a connection between Forkhead box O3a protein and coronary artery disease, yet the exact role of FOXO3a in the regulation of metabolic processes and apoptosis in vascular endothelial cells is still unknown. Therefore, we investigated the role of FOXO3a on target genes in a human vascular endothelial cell line. Through the utilization of high-throughput sequencing technology, we analyzed gene expression profiles and alternative splicing patterns in human vascular endothelial cells with FOXO3a over expression.