Histone acetylation landscape in S. cerevisiae nhp6ab mutants reflects altered glucose metabolism.

Background: The execution of many genetic programs, influenced by environmental conditions, is epigenetically controlled. Thus, small molecules of the intermediate metabolism being precursors of most of nutrition-deriving epigenetic modifications, sense the cell surrounding environment.

Methods: Here we describe histone H4K16 acetylation distribution in S.

A novel role for Nhp6 proteins in histone gene regulation in Saccharomyces cerevisiae.

Maintaining a stable and balanced histone pool is of paramount importance for genome stability and fine regulation of DNA replication and transcription. This involves a complex regulatory machinery, exploiting transcription factors as well as histone chaperones, chromatin remodelers and modifiers. The functional details of this machinery are as yet unclear.