Tear clearance measurement in patients with dry eye syndrome using quantitative lacrimal scintigraphy.

Objective: The aim of this study was to evaluate the tear clearance in patients with dry eye syndrome using quantitative lacrimal scintigraphy.

Materials And Methods: We investigated 21 patients (42 eyes; 18 women, 3 men; mean age, 63.19 +/- 13.

Silicone versus collagen plugs for treating dry eye: results of a prospective randomized trial including lacrimal scintigraphy.

Purpose: To compare the short-term efficacy of collagen and silicone plugs for treating dry eye using quantitative lacrimal scintigraphy.

Design: Prospective randomized clinical trial.

Methods: In this institutional study, 24 dry eye patients were evaluated in two groups: group I (n = 22 eyes) received collagen plugs and group II (n = 26 eyes) received silicone plugs.

Myositis and scleritis associated with Behcet's disease: an atypical presentation.

We report a case of an 18-year-old female, who was diagnosed as having systemic Behcet's disease with chief complaints of vision loss in the right eye and redness and pain in both eyes. In addition to an anterior necrotizing scleritis, she had several attacks of retrobulbar neuritis and lateral rectus myositis. She responded well to i.

Scleritis associated with sarcoidosis.

Purpose: To review scleritis cases associated with sarcoidosis and to evaluate clinical features, medical treatment, and clinical course.

Methods: Two cases of diffuse anterior scleritis and a nodular scleritis case associated with systemic sarcoidosis were evaluated. Scleritis was the first manifestation of sarcoidosis in two of the patients and the diagnosis of sarcoidosis was confirmed with a conjunctival biopsy.

Topical cyclosporine in the management of shield ulcers.

Purpose: To report our experience with 0.05%-2% topical cyclosporine in the treatment of 4 cases of severe, corticosteroid-resistant, vernal keratoconjunctivitis with shield ulcers.

Methods: Four patients with shield ulcers not responding to medical treatment with topical steroids, antihistamines, and mast-cell stabilizers were treated with 0.

A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis.

Objective: To evaluate the short-term efficacy and safety of topical cyclosporin A 0.05% in the treatment of patients with severe, steroid-resistant atopic keratoconjunctivitis (AKC).

Design: Multicenter, placebo-controlled, double-masked, randomized trial.

Ocular surface changes in keratoconjunctivitis sicca with silicone punctum plug occlusion.

Purpose: To evaluate histopathologic and clinical response to silicone plug insertion in dry eye patients.

Methods: Punctal plugs were placed in 32 eyes of 18 dry eye patients with aqueous deficiency who were on maximum medical therapy and who had Schirmer testing with topical anesthetic measuring less than 5 mm. Pre-treatment and post-treatment (6 weeks and 1 year) evaluations included temporal and inferior quadrant impression cytology examinations, Schirmer-1, BUT, corneal fluorescein and rose-bengal staining patterns and questionnaire scores.

Advanced fusarium keratitis progressing to endophthalmitis.

Purpose: To review the clinical course, treatment, and visual outcomes of keratitis with endophthalmitis caused by the filamentary fungus Fusarium.

Method: One hundred fifty-nine cases of Fusarium keratitis at Bascom Palmer Eye Institute between January 1, 1987 and August 21, 2000 were reviewed. Ten patients with culture-proven Fusarium keratitis progressed to endophthalmitis.

Surgical technique for control of postkeratoplasty myopia, astigmatism, and anisometropia.

Purpose: We previously demonstrated that selective suture removal reduces keratoplasty astigmatism; however, a myopic shift was induced with the increasing number of interrupted sutures removed. This study is an attempt to determine the effects of a modified surgical technique on postkeratoplasty myopia, astigmatism, and anisometropia.

Design: A cohort study compared with historical controls.

Dry eye and delayed tear clearance: "a call to arms.".

Dry eye may activate components of the ocular surface early warning system. Ocular surface stresses in dry eye, such as hyperosmolarity, could activate cellular stress pathways such as MAPKs. IL-1 and MMP-9 produced by the ocular surface epithelial cells may mediate initial events in the inflammatory cascade of dry eye through a dynamic interplay between them on the ocular surface.

Suturing technique for control of postkeratoplasty astigmatism and myopia.

Purpose: We previously demonstrated that selective suture removal reduces keratoplasty astigmatism; however, a myopic shift was induced with increasing number of interrupted sutures removed. This study is an attempt to determine the effects of a modified surgical technique on postkeratoplasty myopia, astigmatism, and anisometropia.

Methods: Optical penetrating keratoplasties were performed on 92 eyes of 84 patients.

Colletotrichum keratitis.

Purpose: To evaluate Colletotrichum keratitis and to report the risk factors and clinical course.

Design: Interventional case series.

Methods: In order to report the clinical course of Colletotichum keratitis, fungal keratitis cases between January 1980 and February 2001 in an institutional setting were retrospectively reviewed and 10 eyes of 9 patients with Colletotrichum keratitis were identified by positive cultures.

A mouse model of keratoconjunctivitis sicca.

Purpose: To evaluate the effects of pharmacologic inhibition of aqueous tear production and desiccating environmental stress on aqueous tear production, tear clearance, corneal epithelial permeability, and conjunctival epithelial morphology, proliferation, and conjunctival goblet cell differentiation.

Methods: Aqueous tear production was inhibited by applying transdermal scopolamine (scop) patches to the depilated midtail of female MC, CBA mice. Desiccating environmental stress was created by placing mice in a hood with a continuous airflow blower.