In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn.

Background: Piper nigrum [Piperaceae], commonly known as black pepper is used as medicine fairly throughout the greater part of India and as a spice globally.

Purpose: To isolate piperine and evaluate in vitro cytotoxic [antiproliferative] activity and in silico method.

Methods: Piperine was isolated from the fruits of P.