Across the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO , ATP, and acetyl-CoA to malonyl-CoA, ADP, and P. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis. ACC is found in two forms, (1) as a heteromeric enzyme, and (2) as a homomeric enzyme.
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