Correlation of clinical phenotype with a pericentric inversion of chromosome 9 and genetic counseling.

Objective: To describe the history of 157 carriers of pericentric inversions on chromosome 9 [inv9] with karyotype analyses and evaluate the significance of these findings.

Methods: We studied the incidence, clinical significance, and genetic counseling of inv9 p11;q12, p11;q13, and p11;q21 patients who were referred to our laboratory from various clinics of the Medical Faculty, Cukurova University, Adana, Turkey retrospectively from 157 cases of 15528 cytogenetic analyses collected between May 1993 and February 2007.

Results: We found the incidence of inv9 to be 1.