Publications by authors named "Dila Atak"
Background: Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) that may lead to progressive disability. Here, we explored the behavioral pattern and the role of vasculature especially PDGFRB+ pericytes/ perivascular cells, in MS pathogenesis.
Methods: We have evaluated vascular changes in two different experimental allergic encephalomyelitis (EAE) mice models (MOG and PLP-induced).
Article Synopsis
- Multiple sclerosis (MS) is an autoimmune condition that affects the central nervous system, leading to issues like demyelination and problems with brain pericytes, which may play a role in the disease's development.
- The research involved using mice to induce a model of MS and examined how serum from these mice and human patients impacted the survival of human brain vascular pericyte (HBVP) cells, using various testing methods.
- Findings indicated that sera from mice with MS and from MS patients led to increased early apoptosis and reduced survival of HBVP cells, suggesting that factors in serum may influence the dysfunction of pericytes in progressive forms of MS.
KIF2A is a kinesin motor protein with essential roles in neural progenitor division and axonal pruning during brain development. However, how different KIF2A alternative isoforms function during development of the cerebral cortex is not known. Here, we focus on three isoforms expressed in the developing cortex.
View Article and Find Full Text PDFExcitatory neurons of the mammalian cerebral cortex are organized into six functional layers characterized by unique patterns of connectivity, as well as distinctive physiological and morphological properties. Cortical layers appear after a highly regulated migration process in which cells move from the deeper, proliferative zone toward the superficial layers. Importantly, defects in this radial migration process have been implicated in neurodevelopmental and psychiatric diseases.
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