[Free fatty acid spectrum and rheological properties of erythrocytes in people with disturbed glucose tolerance and in patients with diabetes mellitus].

The paper is devoted to a study of mechanisms of deterioration of blood rheological properties in disturbed carbohydrate metabolism in 17 patients with disorders in GTT and in 83 patients with diabetes mellitus (DM). The level of lipids, the spectrum of fatty acids (SFA) were determined in the blood plasma using gas chromatography by an original method, proposed by the authors for assessment of the rheological properties of erythrocytes (rotation viscosimetry of erythrocyte suspension in standard hematocrit of 45%). The concentrations of saturated and polyunsaturated acids in the blood plasma of persons with disturbed GTT and DM were increased, and the concentration of linoleic acid was lowered.

[Pathogenetic therapy of tissue hypoxia, hemorheologic disorders and microangiopathies in patients with diabetes mellitus].

To reveal oxygen transport and hemorheological changes in derangements of carbohydrate metabolism, a unified scheme for patients' examination was devised. It includes examination of oxygen metabolism, rheological blood properties (viscosity of the whole blood, hematocrit, viscosity of erythrocyte and plasma suspension), microcirculation and compensatory responses of the body. Identification of oxygen transport disorders and hemorheological shifts, determination of their nature, intensity as well as of the mechanism by which they occur make it possible to form a genuine basis for effective differentiated correction of the abnormalities of the blood rheological properties and tissue hypoxia, and favours stabilization of microangiopathies in patients with diabetes mellitus.

[Blood hyperviscosity syndrome in type I diabetes mellitus].

Blood rheological properties and oxygen metabolism were investigated in 50 patients with type I insulin dependent diabetes mellitus. Metabolic and morphological phases of the blood hyperviscosity syndrome were defined in relation to the nature of hemorheological disturbances. Oxygen metabolic disturbances were of unidirectional type manifesting themselves in a decrease in tissue oxygenation and the development of tissue hypoxia.

[Diagnostic significance of determining glycosylated hemoglobin in the detection of early forms of diabetes mellitus].

In order to determine the diagnostic value of glycolytic hemoglobin (HbA1c) in early forms of diabetes mellitus its content was studied in 62 individuals with disturbed glucose tolerance, then used as a kind of screening for examination of 357 workers employees at a factory with a subsequent glucose tolerance test (GTT). The level of HbA1c was raised almost in all persons with disturbed carbohydrate metabolism. There was correlation between HbA1c and GTT results in the diagnosis of disturbed glucose tolerance.

[Desynchronization of circadian rhythms of the oxygen balance in the tissues and rheological properties of the blood in type I diabetes mellitus].

Circadian rhythms of tissue oxygen balance and blood rheological properties were investigated in 40 patients with insulin dependent diabetes mellitus. The syndrome of blood hyperviscosity determined by a rise of the level of packed cell volume and blood viscosity developed in decompensation of diabetes mellitus, resulting in desynchronization of packed cell volume. Blood viscosity rhythm was preserved but fluctuation ranges were sharply on an increase.

[Diabetic microangiopathy and oxygen transport disorder (a review of the literature and the authors' own data)].

Proceeding from biochemical and instrumental investigations on a vast material (560 patients with various forms of diabetes mellitus) and literature data the authors propose a new concept of occurrence and progression of diabetic microangiopathies. Importance is attached to tissue hypoxia related to an entire complex of hormonal-metabolic changes resulting in a disturbed supply of oxygen to the tissues.

[Contractile function of the myocardium and oxygen metabolism in diabetes mellitus].

Myocardial contractility was studied by the radionuclide cardiography method and oxygen exchange and ABB by Astrup's method in 42 patients with insulin dependent and 50 patients with insulin independent diabetes mellitus. Indicators of tissue oxygenation and hemodynamics were correlated in both types of diabetes mellitus. At the start of disease tissue hypoxia causes compensatory change of hemodynamics, and the hyperkinetic type of the disease develops.

[Dyslipoproteinemia, oxygen-transport system of blood and oxygen balance in the tissues at early stages of diabetes mellitus].

The nature of the blood serum lipoprotein spectrum, blood oxygen transport function and tissue oxygenation were studied in 89 patients with early forms of diabetes mellitus and in 20 healthy persons. A higher level of pre-beta-lipoproteins and beta-lipoproteins was revealed; a lowered level of alpha-lipoproteins was determined above all by triglycerinemia. Hyperlipoproteinemia even at early stages of diabetes mellitus is capable of causing diverse changes in the blood oxygen transport system.

[Dynamics of the level of insulin in blood in response to hydrocortisone loading in myocardial infarction].

To elucidate the details of carbohydrate metabolism in the course of acute myocardial infarction, baseline blood insulin and glucose levels and changes thereof in response to acute hydrocortisone loading were investigated in patients with acute transmural and large-focal myocardial infarction that had developed in the presence of essential hypertension (patients with diabetes mellitus were excluded from the study). Basal hypoinsulinemia was discovered on Day 1 of myocardial infarction in these patients. On Days 3-5 of infarction, blood insulin concentration was increased significantly.

[Blood rheological properties and the oxygen balance of the tissues in experimental alloxan diabetes].

The whole blood viscosity and the tissue oxygen balance were studied in rats and rabbits with alloxan diabetes. An augmentation of the blood viscosity was seen in female rats during diabetes latent period after injecting alloxan in a dose of 100 mg/kg. The blood viscosity is 3 times as high in diabetes, produced by the injection of alloxan in a dose of 200 mg/kg, and is characterized by severe hyperglycemia, simultaneously the tissue oxygen balance alteration is observed.

[Gas composition and acid-base equilibrium of blood of patients operated on under conditions of epidural anesthesia].

The results of the studies on the gas composition and acid-base equilibrium of the blood in patients operated upon under epidural anesthesia have proved the rise of venous hyperoxia and the drop of the gas utilization percentage both in anesthetized and non-anesthetized regions. At the level of the whole organism, however, no essential changes of oxygen metabolism are noted.