Publications by Dikeledi H Mokone

Publications by authors named "Dikeledi H Mokone"

Page 1 of 1

Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co-Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer.

Shingirai M Chiwambutsa Oluwatosin Ayeni Nyasha Kapungu Comfort Kanji Roslyn Thelingwani Dikeledi H Mokone

Clin Pharmacol Ther

July 2023

Article Synopsis

Clinical outcomes of tamoxifen (TAM) treatment show high variability among individuals, influenced by genetic differences and other medications.
A study involving 229 South African Black women with breast cancer found that certain genetic variants (CYP2D6*17 and CYP2D6*29) significantly impact the metabolism of TAM and its active metabolites.
While antiretroviral therapy affected certain metabolite levels of TAM, the overall risk of significant drug interactions was considered low for patients undergoing TAM treatment.

View Article and Find Full Text PDF

Human immunodeficiency virus infection in breast cancer patients: The prevalence thereof and its effect on breast cancer characteristics at Dr. George Mukhari Academic Hospital Breast Clinic, Ga-Rankuwa, South Africa.

Nikoli van Zyl Cornelia Minné Dikeledi H Mokone

SA J Radiol

August 2018

Background: Since the advent of highly active anti-retroviral therapy, improved immune functioning and prolonged survival of Human immunodeficiency virus (HIV)-positive patients has been accompanied by an increased incidence of non-AIDS-defining cancers (NADC). Breast cancer is the most prevalent NADC among HIV-positive women. However, data regarding the interaction between these two diagnoses remain limited.

View Article and Find Full Text PDF