Oral diseases are often caused by bacterial infections, making the inhibition of receptors like -acetylglucosamine critical in preventing bacterial formation. The plant () is known for its diverse bioactivities and may serve as a promising source for developing new antibacterial agents. This study employs in silico methods to predict the inhibitory mechanisms, pharmacokinetics, and drug-likeness of compounds isolated from .
View Article and Find Full Text PDFAntioxidants are compounds that can inhibit excessive free radical reactions in the body. Excessive free radicals can cause system imbalances in the body which can trigger oxidative stress and cause serious illness. The limitations of antioxidants in the body can be overcome by consuming safe natural additional antioxidants that can be obtained from natural products.
View Article and Find Full Text PDFThe WHO Global Status Report on Oral Health 2022 reveals that oral diseases caused by infection with oral pathogenic microorganisms affect nearly 3.5 billion people worldwide. Oral health problems are caused by the presence of and in the oral cavity.
View Article and Find Full Text PDFThe oral cavity is an excellent place for various microorganisms to grow. and are Gram-negative bacteria found in the oral cavity as pioneer biofilm formers on the tooth surface that cause caries. Caries treatment has been done with antibiotics and therapeutics, but the resistance level of and bacteria necessitates the exploration of new drug compounds.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2024
L., commonly known as Kelor in Indonesia and miracle tree in English, has a rich history of utilization for medicinal, nutritional, and water treatment purposes dating back to ancient times. The plant is renowned for its abundance of vitamins, minerals, and various chemical constituents, making it a valuable resource.
View Article and Find Full Text PDFAlong with the increasing resistance of spp. to some antibiotics, it is necessary to find new antifungal drugs, one of which is from the medicinal plant Red Betel (). The purpose of this research is to isolate antifungal constituents from and evaluate their activities as ergosterol biosynthesis inhibitors via an in silico study of ADMET and drug-likeness analysis.
View Article and Find Full Text PDFBreast cancer is a significant global concern, with tamoxifen, the standard treatment, raising long-term safety issues due to side effects. In this study, we evaluated the potential of five onoceranoid triterpenes from Corr. cv.
View Article and Find Full Text PDFMycoses or fungal infections are a general health problem that often occurs in healthy and immunocompromised people in the community. The development of resistant strains in and the incidence of azole antibiotic resistance in the Asia Pacific which reached 83% become a critical problem nowadays. To control fungal infections, substances and extracts isolated from natural resources, especially in the form of plants as the main sources of drug molecules today, are needed.
View Article and Find Full Text PDFAim: The SARS-CoV-2 virus is a disease that has mild to severe effects on patients, which can even lead to death. One of the enzymes that act as DNA replication is the main protease, which becomes the main target in the inhibition of the SARS-CoV-2 virus. In finding effective drugs against this virus, is a potential herbal plant because it has been tested to have high phytochemical content and bioactivity.
View Article and Find Full Text PDFCorr. is a member of the Meliaceae family that is widely spread in tropical and subtropical region of Asia and America. Traditionally, the fruit of this plant has been consumed because of its sweet taste.
View Article and Find Full Text PDFhas been used as an alternative medicine for wounds, smallpox, cervical cancer, and breast cancer. This plant is a potential source of new plant-derived drugs to cure numerous diseases for its multiple therapeutic functions. An in vitro study revealed that the methanol extract of (stem) exhibits antioxidant activity according to DPPH and SOD methods, with IC values of 33 and 8.
View Article and Find Full Text PDFBackground: Cancer is the second leading cause of death in the world. Leukemia is a type of cancer that accounts for 31.5% of all cancers in children under the age of 15 in industrialized countries and 15.
View Article and Find Full Text PDFAdv Appl Bioinform Chem
December 2022
Introduction: Uncontrolled biofilm can cause several diseases such as dental caries, gingivitis, and periodontitis. Dental caries is a disease caused by the accumulation of plaque-containing pathogenic bacteria, including . These bacteria infect the root canals of teeth and colonize to form biofilms.
View Article and Find Full Text PDFAndrogenic alopecia (AA) is a condition that most commonly affects adult men and is caused by an increase in the hormone dihydrotestosterone (DHT) in the hair follicles. Anti-alopecia drugs should be discovered for hair follicles to enter the anagen growth phase. Therefore, this study evaluated the hair growth-promoting activity of Noni fruit’s water, ethyl acetate, n-hexane fractions, and sub-fractions from the active fraction in the alopecia male white rabbit model.
View Article and Find Full Text PDFAntioxidants are compounds that are able to inhibit the negative effects that come from free radicals. The phenomenon of imbalanced antioxidant production and the accumulation of free radicals in cells and tissues can cause oxidative stress. Excessive free radicals that enter the body cannot be warded off by endogenous antioxidant compounds so that the required antioxidant compounds can come from the outside, which helps in the performance of endogenous antioxidants.
View Article and Find Full Text PDFRoxb. is a plant from Southeast Asia and is widely used as an alternative medicine with various applications. This plant has been widely used in traditional medicine.
View Article and Find Full Text PDFInfection by bacteria is one of the main problems in health. The use of commercial antibiotics is still one of the treatments to overcome these problems. However, high levels of consumption lead to antibiotic resistance.
View Article and Find Full Text PDFRice ( L.) is a primary food that is widely consumed throughout the world, especially in Asian countries. The two main subspecies of rice are and which are different in physical characteristics.
View Article and Find Full Text PDFComb Chem High Throughput Screen
June 2023
Background: is one of the bacteria that contributes to biofilm formation and causes dental caries. The inhibition of SrtA, gbpC, and Ag I/II is a promising target to be developed as an antibacterial. is known to have antibacterial activity.
View Article and Find Full Text PDFChemical characteristics of natural products are influenced by different external factors, varying according to the geographic origin. The ethanol extract of L calyx Indonesia has been studied and provide potential effect for dental field uses. Ethanol extract showed antibacterial to as an inducer gingivitis, had an effect on the treatment of oral mucosa ulceration, and could inhibit the development of alveolar bone destruction.
View Article and Find Full Text PDFCoronavirus disease-2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 attacking the lungs, which contain the most oxygen. The involvement of oxidative stress in the body and the role of antioxidant compounds, namely catechins, are thought to be able to prevent various diseases, including the COVID-19 infection virus. An approach was employed between the catechins and the protein NADPH oxidase (Nox), followed by the coronavirus protease protein, to limit the generation of reactive oxygen species.
View Article and Find Full Text PDFThe prevalence of oral health problems in the global population is still high, especially dental caries, which is considered a multifactorial disease involving the role of bacteria, namely . Gram-positive bacteria metabolize carbohydrates and sugars and convert them into lactic acid, causing dental caries. The peptidoglycan (PG) layer at the outer surface of the bacteria acts as protection.
View Article and Find Full Text PDFBased on data from The Global Burden of Disease Study in 2016, dental and oral health problems, especially dental caries, are a disease experienced by almost half of the world's population (3.58 billion people). One of the main causes of dental caries is the pathogenesis of .
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