Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry.

Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.

Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup.

Progressive resistance training for persons with intellectual disabilities and visual impairment.

Background: Knowledge concerning the feasibility and effects of progressive resistance training (PRT) for persons with intellectual disabilities and visual impairment who are categorized in Gross Motor Function Classification System (GMFCS) Level 1 is limited. The aim of our study was to evaluate feasibility and effect of PRT on participants' Quadriceps strength and personal goals.

Methods: Eight Participants followed a PRT program for 10 weeks.

Measuring Quadriceps strength in adults with severe or moderate intellectual and visual disabilities: Feasibility and reliability.

Background: A feasible and reliable instrument to measure strength in persons with severe intellectual and visual disabilities (SIVD) is lacking. The aim of our study was to determine feasibility, learning period and reliability of three strength tests.

Methods: Twenty-nine participants with SIVD performed the Minimum Sit-to-Stand Height test (MSST), the Leg Extension test (LE) and the 30 seconds Chair-Stand test (30sCS), once per week for 5 weeks.

Validity of the modified Berg Balance Scale in adults with intellectual and visual disabilities.

Background: A modified version of the Berg Balance Scale (mBBS) was developed for individuals with intellectual and visual disabilities (IVD). However, the concurrent and predictive validity has not yet been determined.

Aim: The purpose of the current study was to evaluate the concurrent and predictive validity of the mBBS for individuals with IVD.

The impact of visual impairment on the ability to perform activities of daily living for persons with severe/profound intellectual disability.

Background: The ability to perform activities of daily living (ADL) as a component of participation is one of the factors that contribute to quality of life. The ability to perform ADL for persons experiencing severe/profound intellectual disability (ID) may be reduced due to their cognitive and physical capacities. However, until recently, the impact of the significantly prevalent visual impairments on the performance of activities of daily living has not yet been revealed within this group.

Feasibility, test-retest reliability, and interrater reliability of the Modified Ashworth Scale and Modified Tardieu Scale in persons with profound intellectual and multiple disabilities.

Caregivers of persons with profound intellectual and multiple disabilities (PIMD) often describe the quality of the daily movements of these persons in terms of flexibility or stiffness. Objective outcome measures for flexibility and stiffness are muscle tone or level of spasticity. Two instruments used to grade muscle tone and spasticity are the Modified Ashworth Scale (MAS) and the Modified Tardieu Scale (MTS).

A case of extreme agitation and death after the use of mephedrone in The Netherlands.

A 36-year old man, having injured himself severely by smashing windows in a rage of fury, was arrested by the police. He died despite resuscitation attempts. The forensic autopsy showed many superficial skin lacerations, bruises and minor brain swelling, but there was no definitive cause of death.

The concentration of oxazepam and oxazepam glucuronide in oral fluid, blood and serum after controlled administration of 15 and 30 mg oxazepam.

Aims: To measure and compare the concentration-time profiles of oxazepam and oxazepam glucuronide in blood, serum and oral fluid within the scope of roadside testing.

Methods: Biological samples were collected from eight male subjects after ingestion of 15 or 30 mg oxazepam on separate dosing occasions with an interval of 7 days. The concentration-time profiles of oxazepam and oxazepam glucuronide were fitted by using a one-compartment model.

Quantitative analysis of 33 benzodiazepines, metabolites and benzodiazepine-like substances in whole blood by liquid chromatography-(tandem) mass spectrometry.

A quantitative method using high-performance liquid chromatography-mass spectrometry (LC-MS, ion trap) after matrix supported liquid-liquid extraction is described for the simultaneous determination in whole blood of 33 benzodiazepines including metabolites and benzodiazepine-like substances. The limits of detection (LOD) range from 0.0001 to 0.

The risk of the introduction of classical swine fever virus at regional level in the European Union: a conceptual framework.

Recent classical swine fever (CSF) epidemics in the European Union (EU) have clearly shown that preventing the introduction of CSF virus (CSFV) deserves high priority. Insight into all the factors contributing to the risk of CSFV introduction is a prerequisite for deciding which preventive actions are cost-effective. The relations between virus introduction and spread, prevention and control, and economic losses have been described using the conceptual framework presented in this paper.

Probability of and risk factors for introduction of infectious diseases into Dutch SPF dairy farms: a cohort study.

A 2-year cohort study was conducted to investigate the probability of disease introduction into Dutch dairy farms. The farms were tested regularly for diseases and were visited biannually to collect management data. Ninety-five specific pathogen-free (SPF) dairy farms were selected from a database of bovine herpesvirus type 1 (BHV1)-free farms to study the probability of, and risk factors for, introduction of BHV1, bovine viral diarrhoea virus (BVDV), Salmonella enterica subsp.

A concept for a decision support system based on practical experiences from a national disease emergency. The Dutch experience.

In 1997-1998, the Netherlands experienced a large epidemic of classical swine fever (CSF). The magnitude of this epidemic stressed the role information systems could play in supporting the management during an eradication campaign. The enforcement of an eradication strategy can become very complicated, especially with large epidemics, due to time pressure and many different procedures that have to be executed at the same time.

An economic model for on-farm decision support of management to prevent infectious disease introduction into dairy farms.

A more-closed farming system can be a good starting point for eradication of infectious diseases from within a herd. The economic implications of a more-closed farming system will not always be obvious to farmers. The management decisions are related to different parts of the farm and are farm-specific.

Risk factors for introduction of BHV1 into BHV1-free Dutch dairy farms: a case-control study.

In May 1998, a compulsory eradication programme for BHV1 started in the Netherlands. In December 1999 approximately 24% of Dutch dairy farms were certified BHV1-free (Animal Health Service (AHS)). Ninety-three certified BHV1-free dairy farms participated in a cohort study that investigated the probability of introduction of infectious diseases.

Spatial and stochastic simulation to compare two emergency-vaccination strategies with a marker vaccine in the 1997/1998 Dutch Classical Swine Fever epidemic.

Two alternative emergency-vaccination strategies with a marker vaccine that could have been applied in the 1997/1998 Dutch Classical Swine Fever (CSF) epidemic were evaluated in a modified spatial, temporal and stochastic simulation model: InterCSF. In strategy 1, vaccination would be applied only to overcome a shortage in destruction capacities. Destruction of all pigs on vaccinated farms distinguishes this strategy from strategy 2, which assumes intra-Community trade of vaccinated pig meat.

Optimization of dairy heifer management decisions based on production conditions of Pennsylvania.

We used a dynamic programming model to determine optimum rearing decisions of dairy replacements. Heifers were described in the model by age, season, body weight, pregnancy state, and prepubertal growth rate. Prices and parameters were chosen to represent the dairy population of Pennsylvania.

Use of AI technician scores for body condition, uterine tone and uterine discharge in a model with disease and milk production parameters to predict pregnancy risk at first AI in Holstein dairy cows.

Technicians recorded body condition score (BCS) and several parameters related to estrus and/or metritis for 1694 first insemination cows on 23 farms. Additional variables for modeling the adjusted odds ratios (OR) for pregnancy were data on disease prior to or within 21 days of AI and test day milk yields. Significant predictors for pregnancy were farm, year and season, BCS, uterine tone, contaminated insemination gun after AI, fat-protein corrected kilograms milk (FPCM), days in milk (DIM), and diseases.

Evaluating control strategies for outbreaks in BHV1-free areas using stochastic and spatial simulation.

Several countries within the EU have successfully eradicated bovine herpesvirus type I (BHV1), while others are still making efforts to eradicate the virus. Reintroduction of the virus into BHV1-free areas can lead to major outbreaks - thereby causing severe economic losses. To give decision-makers more insight into the risk and economic consequences of BHV1 reintroduction and into the effectiveness of various control strategies, we developed the simulation model InterIBR.

Spatial and stochastic simulation to evaluate the impact of events and control measures on the 1997-1998 classical swine fever epidemic in The Netherlands. II. Comparison of control strategies.

Using the spatial, temporal and stochastic simulation model InterCSF, several alternative pre-emptive slaughter strategies that could have been applied in the Dutch Classical Swine Fever (CSF) epidemic of 1997-1998 were evaluated. Furthermore, effects of changes in some disease-spread and disease-control parameters were studied. InterCSF simulates the spread of CSF between farms through local spread and contacts (animals, transport and persons).

Spatial and stochastic simulation to evaluate the impact of events and control measures on the 1997-1998 classical swine fever epidemic in The Netherlands. I. Description of simulation model.

The simulation model InterCSF was developed to simulate the Dutch Classical Swine Fever (CSF) epidemic of 1997-98 as closely as possible. InterCSF is a spatial, temporal and stochastic simulation model. The outcomes of the various replications give an estimate of the variation in size and duration of possible CSF-epidemics.

A model to estimate the financial consequences of classical swine fever outbreaks: principles and outcomes.

A model is presented aimed at a financial analysis of a Classical Swine Fever outbreak. Financial consequences are calculated for affected parties, including governments (EU and national), farms, and related industries in the production chain. The model can be used to calculate the losses of a real outbreak as well as of a simulated one.

The effectiveness of routine serological surveillance: case study of the 1997 epidemic of classical swine fever in The Netherlands.

The authors describe the value of routine serological surveillance in detecting the introduction of classical swine fever virus into a disease-free population. The first investigation concerned the question of whether the epidemic of classical swine fever (CSF), which occurred from 1997 to 1998 in the Netherlands, could have been detected using the existing monitoring system for notifiable diseases. The investigation used data from the CSF epidemic of 1997/1998 and from the existing monitoring system.

Monte Carlo simulation of virus introduction into the Netherlands.

In order to improve the understanding of the risk of introducing classical swine fever (CSF) and foot-and-mouth disease (FMD) into the Netherlands, a Monte Carlo simulation model was developed. The model, VIRiS (Virus Introduction Risk Simulation model) describes virus introduction into the Netherlands from outbreaks in other European countries. VIRiS is aimed at supporting decision makers involved in disease prevention.

Modeling the effect of an outbreak of bovine herpesvirus type 1 on herd-level milk production of Dutch dairy farms.

One of the impacts of disease is its effect on milk production. In the present study the effect of an outbreak of bovine herpesvirus type 1 on milk production at the herd level of certified bovine herpesvirus type 1-free dairy farms was modeled. The objective was to study several linear models to quantify the effects of a bovine herpesvirus type 1 outbreak on milk production accounting for the repeated measurements and incorporating our assumptions about the most likely duration of effects of this virus.