Publications by authors named "Digjaya Utama"
Reticulocyte Binding Protein Homologue (RH5), a leading malaria vaccine candidate, is essential for erythrocyte invasion by the parasite, interacting with the human host receptor, basigin. RH5 has a small number of polymorphisms relative to other blood-stage antigens, and studies have shown that vaccine-induced antibodies raised against RH5 are strain-transcending, however most studies investigating RH5 diversity have been done in Africa. Understanding the genetic diversity and evolution of malaria antigens in other regions is important for their validation as vaccine candidates.
View Article and Find Full Text PDFPurpose: This study aimed to compare postoperative ejection fraction (EF) in response to coronary artery bypass grafting (CABG) among patients with preoperative EF <35% and >35%.
Methods: A retrospective study was conducted in a single institution using clinical data of 660 patients undergoing elective on-pump CABG in 2018-2019. Patients were classified into two groups based on preoperative left ventricle ejection fraction (<35% and >35%).
Article Synopsis
- PfEMP1 is crucial for malaria severity because it binds to ICAM1 in the brain's blood vessels, contributing to severe cerebral malaria.
- A study in Papua New Guinea found that higher antibody levels to the specific PfEMP1 domain, DBLβ3, were linked to a significantly lower risk of both high-density and low-density malaria in young children.
- Children with severe malaria had lower antibody levels to DBLβ3 compared to those with non-severe cases, indicating a potential link between immune response and disease severity, which may aid in vaccine development.