Publications by authors named "Diez-Roux A"

Article Synopsis
  • The paper investigates the obesity transition related to socioeconomic status (SES), gender, and age in cities of Colombia and Mexico using data from the SALURBAL study.
  • A system dynamics model simulates BMI categories from national health surveys collected between 2010-2016, projecting trends in obesity from 2010 to 2050.
  • Results indicate that while lower SES adults in both countries face increasing obesity rates, the patterns differ by gender, especially with Mexican women showing a faster rise in obesity rates among higher SES groups.
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Despite the relevance of cities and city policies for health, there has been limited examination of large numbers of cities aimed at characterizing urban health determinants and identifying effective policies. The relatively few comparative studies that exist include few cities in lower and middle income countries. The Salud Urbana en America Latina study (SALURBAL) was launched in 2017 to address this gap.

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Objective: The United States has a lower life expectancy and wider income inequality than its similarly developed counterparts, and disparities continue to widen. The objective of our study is to examine the heterogeneity of disparities by income in cardiovascular disease (CVD) risk factors among U.S.

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Climate hazards threaten the health and wellbeing of people living in urban areas. This study characterized reported climate hazards, adaptation action, and barriers to adaptation in 124 Latin American cities, and associations of climate hazards with urban social and built environment characteristics. We examined cities that responded to a global environmental disclosure system and that were included in the Urban Health in Latin America (SALURBAL) Project database.

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Importance: Epigenetic age acceleration is associated with exposure to social and economic adversity and may increase the risk of premature morbidity and mortality. However, no studies have included measures of structural racism, and few have compared estimates within or across the first and second generation of epigenetic clocks.

Objective: To determine whether epigenetic age acceleration is positively associated with exposures to diverse measures of racialized, economic, and environmental injustice measured at different levels and time periods.

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Objective: Drunk driving is a major cause of road traffic injuries and deaths in Latin America. We evaluated the impact of a drunk driving intervention in Leon, Mexico on road traffic safety.

Methods: The intervention included increased drunk driving penalties, enhanced sobriety checkpoints and a young adult-focused mass media campaign, beginning 19 December 2018.

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Housing is a pressing problem worldwide and a key determinant of health and wellbeing. The right to adequate housing, as a pillar of the right to an adequate standard of living, means more than a roof to live under. Adequate means the dwelling must fulfill material functions and psychosocial functions, thus contributing to dwellers health and wellbeing.

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Article Synopsis
  • Climate change is causing more flooding, especially in cities in Latin American countries where people have less money.
  • The study looked at 276 cities and found that neighborhoods with lower education levels have a lot more flooding.
  • It's really important for leaders to focus on helping these neighborhoods deal with floods because people there are at higher risk.
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Background: Assessing the trends in dietary GHGE considering the social patterning is critical for understanding the role that food systems have played and will play in global emissions in countries of the global south. Our aim is to describe dietary greenhouse gas emissions (GHGE) trends (overall and by food group) using data from household food purchase surveys from 1989 to 2020 in Mexico, overall and by education levels and urbanicity.

Methods: We used cross-sectional data from 16 rounds of Mexico's National Income and Expenditure Survey, a nationally representative survey.

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Background: Transportation policies can impact health outcomes while simultaneously promoting social equity and environmental sustainability. We developed an agent-based model (ABM) to simulate the impacts of fare subsidies and congestion taxes on commuter decision-making and travel patterns. We report effects on mode share, travel time and transport-related physical activity (PA), including the variability of effects by socioeconomic strata (SES), and the trade-offs that may need to be considered in the implementation of these policies in a context with high levels of necessity-based physical activity.

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Ambient air pollution is a health concern in Latin America given its large urban population exposed to levels above recommended guidelines. Yet no studies have examined the mortality impact of air pollutants in the region across a wide range of cities. We assessed whether short-term levels of fine particulate matter (PM) from modeled estimates, are associated with cardiovascular and respiratory mortality among adults in 337 cities from 9 Latin American countries.

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Precision prevention embraces personalized prevention but includes broader factors such as social determinants of health to improve cardiovascular health. The quality, quantity, precision, and diversity of data relatable to individuals and communities continue to expand. New analytical methods can be applied to these data to create tools to attribute risk, which may allow a better understanding of cardiovascular health disparities.

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Article Synopsis
  • Systemic reforms in public health infrastructure are essential to prepare for future crises and reduce the risk of mass fatalities.
  • Effective communication and coordination among various health agencies and governments are crucial for a rapid response during emergencies.
  • Investments in preventive measures, research, and community resilience can enhance overall public health outcomes and mitigate the impact of potential threats.
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Importance: DNA methylation (DNAm) provides a plausible mechanism by which adverse exposures become embodied and contribute to health inequities, due to its role in genome regulation and responsiveness to social and biophysical exposures tied to societal context. However, scant epigenome-wide association studies (EWAS) have included structural and lifecourse measures of exposure, especially in relation to structural discrimination.

Objective: Our study tests the hypothesis that DNAm is a mechanism by which racial discrimination, economic adversity, and air pollution become biologically embodied.

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The neighborhoods where individuals reside shape environmental exposures, access to resources, and opportunities. The inequitable distribution of resources and opportunities across neighborhoods perpetuates and exacerbates cardiovascular health inequities. Thus, interventions that address the neighborhood environment could reduce the inequitable burden of cardiovascular disease in disenfranchised populations.

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Background: Health research on ambient nitrogen dioxide (NO) is sparse in Latin America, despite the high prevalence of NO-associated respiratory diseases in the region. This study describes within-city distributions of ambient NO concentrations at high spatial resolution and urban characteristics associated with neighbourhood ambient NO in 326 Latin American cities.

Methods: We aggregated estimates of annual surface NO at 1 km spatial resolution for 2019, population counts, and urban characteristics compiled by the SALURBAL project to the neighbourhood level (ie, census tracts).

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Green vegetation may protect against heat-related death by improving thermal comfort. Few studies have investigated associations of green vegetation with heat-related mortality in Latin America or whether associations are modified by the spatial configuration of green vegetation. We used data from 323 Latin American cities and meta-regression models to estimate associations between city-level greenness, quantified using population-weighted normalized difference vegetation index values and modeled as three-level categorical terms, and excess deaths from heat (heat excess death fractions [heat EDFs]).

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Article Synopsis
  • - The study investigates how COVID-19 death rates vary across neighborhoods in Bariloche, Argentina, revealing significant health disparities linked to socioeconomic factors.
  • - Analysis showed that neighborhoods with higher deprivation had nearly double the age-adjusted death rates compared to more affluent areas, emphasizing a strong social gradient in health outcomes.
  • - The findings underscore the need for targeted health interventions that address intraurban inequalities and consider neighborhood-level characteristics to improve public health responses.
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Article Synopsis
  • Researchers looked at how the environment and people's backgrounds in cities affect how adults rate their health in four Latin American countries.
  • They studied data from over 69,000 adults living in various neighborhoods and cities.
  • They found that better local services and a good social environment related to better self-rated health, while the buildings and demographics didn't seem to matter as much.
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Background: Despite global interest in gender disparities and social determinants of hypertension, research in urban areas and regions with a high prevalence of hypertension, such as Latin America, is very limited. The objective of this study was to examine associations of individual- and area-level socioeconomic status with hypertension in adults living in 230 cities in eight Latin America countries.

Methods: In this cross-sectional study, we used harmonized data from 109,184 adults (aged 18-97 years) from the SALURBAL (Salud Urbana en America Latina/Urban Health in Latin America) project.

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Article Synopsis
  • Epigenetic clocks help scientists understand how different factors affect healthy aging, including social conditions, but there isn’t enough focus on who the participants in studies are.
  • The characteristics of participants, like age, gender, and race, are important since they can influence results and health outcomes.
  • Many studies don’t report this information well, making it hard for other researchers to know if the models they create will work for different kinds of people.
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Background: Cable cars are part of the transport system in several cities in Latin America, but no evaluations of their effects on physical activity are available. TransMiCable is the first cable car in Bogotá, Colombia, and the wider intervention includes renovated parks and playgrounds. We assessed the effects of TransMiCable and the wider intervention on physical activity.

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Background: The association of the built environment and the structural availability of services/amenities with adolescent birth rates (ABR) has been overlooked in Latin America. We investigated the association of the availability, and changes in the availability, of services/amenities with ABR in 92 Mexican cities.

Methods: We estimated ABR using data on live birth registration linked to municipality of residence at the time of birth from 2008-2017.

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Studies of life expectancy (LE) in small areas of cities are relatively common in high-income countries but rare in Latin American countries. Small-area estimation methods can help to describe and quantify inequities in LE between neighborhoods and their predictors. Our objective was to analyze the distribution and spatial patterning of LE across small areas of Ciudad Autónoma de Buenos Aires (CABA), Argentina, and its association with socioeconomic characteristics.

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