Development of a two-component recombinant vaccine for COVID-19.

Introduction: Though COVID-19 as a public health emergency of international concern (PHEIC) was declared to be ended by the WHO, it continues to pose a significant threat to human society. Vaccination remains one of the most effective methods for preventing COVID-19. While most of the antigenic regions are found in the receptor binding domain (RBD), the N-terminal domain (NTD) of the S protein is another crucial region for inducing neutralizing antibodies (nAbs) against COVID-19.

Latent profiles of problem-solving skills and their association with depressive symptoms in parents of children with cancer: A cross-sectional study.

Objective: Depressive symptoms are prevalent among parents of children with cancer, significantly impacting their well-being. Problem-solving skills, strongly linked to depressive symptoms, offer a promising avenue for intervention. This study aimed to identify latent profiles of parental problem-solving skills and evaluate differences in depressive symptoms across these profiles.

Association between asthma and cardiovascular disease: evidence from the national health and nutrition examination survey 1999-2018.

Background: Cardiovascular disease(CVD) remains a significant global challenge. Asthma, which is characterized by airway hyperresponsiveness and reversible and limited airflow, plays an important role in cardiovascular diseases. This study aimed to investigate the association between asthma and CVD.

Natural ingredients in the regulation of abnormal lipid peroxidation: a potential therapy for pulmonary diseases.

Pulmonary diseases are a major category of diseases that pose a threat to human health. The most common drugs currently used to treat lung diseases are still chemical drugs, but this may lead to drug resistance and damage to healthy organs in the body. Therefore, developing new drugs is an urgent task.

Sensitivity and Specificity of Three Measures of Intrinsic Capacity in Older People Aged 80 and Over in Nursing Homes.

Purpose: Intrinsic capacity (IC), a crucial indicator for the United Nations Decade of Healthy Ageing 2021-2030, is defined by WHO as the foundation of functional ability, representing the composite of all physical and mental capacities of an individual. IC spans five function domains: Locomotor, psychological, cognitive, vitality, and sensory (including vision and hearing). Accurate IC assessment is vital for effective interventions, yet comparative analyses of these tools are scarce.

Extraction, detection, bioactivity, and product development of luteolin: A review.

Luteolin is a kind of natural flavonoid, widely existing in a variety of plants, has been revealed to have a wide range of biological activities. In recent years, the research results of luteolin are abundant. Here we review the latest research results of luteolin in order to provide new ideas for further research and development of luteolin.

Integrated metabolomics and proteomics analysis reveals the accumulation mechanism of bioactive components in .

(Mill.) Druce is rich in bioactive components with high medicinal value. To maximize the clinical benefits, it is of great significance to efficiently extract key bioactive components from appropriate growth stages in which they are most abundant.

Relay intercropped soybean promotes nodules development and nitrogen fixation by root exudates deposition.

Background: Legumes, in the initial event of symbiosis, secrete flavonoids into the rhizosphere to attract rhizobia. This study was conducted to investigate the relationship between crop root exudates and soybean nodule development under intercropping patterns.

Method: A two years field experiments was carried out and combined with pot experiments to quantify the effects of planting mode, i.

Pulmonary Mucormycosis in an Older Acute Myeloid Leukemia Patient.

Mucormycosis is a rare but fatal opportunistic fungal infection. Patients with hematologic malignancies who use immunosuppressant and glucocorticoid extensively are susceptible to mucormycosis. We report a case of an older patient with acute myeloid leukemia (AML) who was infected with pulmonary mucormycosis during chemotherapy.

Artificial intelligence model predicts M2 macrophage levels and HCC prognosis with only globally labeled pathological images.

Background And Aims: The levels of M2 macrophages are significantly associated with the prognosis of hepatocellular carcinoma (HCC), however, current detection methods in clinical settings remain challenging. Our study aims to develop a weakly supervised artificial intelligence model using globally labeled histological images, to predict M2 macrophage levels and forecast the prognosis of HCC patients by integrating clinical features.

Methods: CIBERSORTx was used to calculate M2 macrophage abundance.

Bibliometric study on the utilization of sorafenib in hepatocellular carcinoma.

Background: Although the number of studies on sorafenib for hepatocellular carcinoma (HCC) is increasing during the past two decades, no detailed scientometric examination of its knowledge framework has been undertaken. Therefore, we performed a bibliometric analysis on this topic.

Methods: VOSviewer and CiteSpace were utilized to analyze the articles regarding sorafenib for HCC from 2005 to 2024, which were retrieved from the Web of Science Core Collection (WoSCC) database.

Peritoneal adipose stem cell-derived extracellular vesicles mediate the regulation of ovarian cancer cell proliferation and migration through EGFR-NF-κB signaling.

Peritoneal dissemination frequently develops in patients with ovarian cancer (OC) and is associated with recurrence and metastasis. However, the cellular components and mechanisms supporting OC peritoneal metastasis are poorly understood. To elucidate these, we utilized RNA sequencing to investigate the cellular composition and function.

Melatonin ameliorates -associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes.

Although the pathogenesis and mechanism of congenital skeletal dysplasia are better understood, progress in drug development and intervention research remains limited. Here we report that melatonin treatment elicits a mitigating effect on skeletal abnormalities caused by deficiency. In addition to our previous finding of endoplasmic reticulum stress upon deficiency, we found calcium (Ca) overload jointly contributed to -associated chondrodysplasias.

C5aR1-positive adipocytes mediate non-shivering thermogenesis in neonatal mice.

Brown adipose tissue (BAT) plays an important role in maintaining body temperature in newborn mammals; however, its mechanisms remain poorly understood. Here, we report the identification of a special population of brown adipose tissue-derived stromal cells (ASCs) in neonatal mice that highly express CD45 and can be differentiated into adipocytes with lower thermogenic ability. These CD45 adipocytes also characteristically contained complement C5a receptor 1(C5aR1) on the cell membrane.

Partial cystectomy as a surgical option for colorectal cancer patients with pathological bladder invasion: an original retrospective study.

Background: Limited research exists on colorectal cancer (CRC) patients with bladder invasion, with survival outcomes post-cystectomy underexplored and a debate between partial and total cystectomy ongoing.

Objective: The study aimed to evaluate the effect of pathological bladder invasion on the long-term tumour prognosis of patients with clinically diagnosed bladder invasion in CRC after cystectomy.

Design: Retrospective, cohort study.

Hydrophobic dual-polymer-reinforced graphene composite aerogel for efficient water-oil separation.

Addressing the environmental challenges posed by oil spills and industrial wastewater is critical for sustainable development. Graphene aerogels demonstrate significant potential as highly efficient adsorbents due to their high specific surface area, excellent structural tunability and outstanding chemical stability. Among available fabrication methods, the hydrothermal self-assembly technique stands out for its low cost, high tunability and good scalability.

Preparation of a lanthanum-modified flocculant and its removal performance towards phosphorus and fluoride in yellow phosphorus wastewater.

Polysilicate-ferric-calcium-lanthanum (PSFCL) was synthesized through a co-polymerization method in order to treat the yellow phosphorus wastewater. Its morphology, composition and functional group were analyzed by X-ray Diffraction (XRD), Fourier Transform-Infrared Spectroscopy (FTIR), Scanning Electron Microscopic (SEM) and X-ray Photoelectron Spectroscopy (XPS), respectively. The optimization of the flocculant was also investigated, including La/Si molar ratio, pH, agitation time, dosage and sedimentation time.

Genetically engineered gas vesicle proteins with proliferative potential for synergistic targeted tumor therapy.

Nanomedicine enables precision-targeted therapies through a non-invasive approach, and nanoparticles may be biologically affected during their colonization . Ensuring the efficient expression of their performance , while ensuring biosafety, is of great significance. Previous studies have employed genetically engineered following entry as a genetically engineered targeting synergist, to enhance the effect of focused ultrasound ablation by exploiting its targeted colonization of tumor tissue.

Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study.

Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.

Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.

The landscape of recurrent spontaneous abortion registered on clinical trials.gov.

Objective: Recurrent spontaneous abortion (RSA) presents a significant challenge in the field of reproductive medicine, as effective treatments remain limited despite extensive research efforts. A comprehensive understanding of current RSA clinical trials is essential for enhancing trial design and identifying existing research gaps. The aim of this study is to characterize RSA related clinical trials registered on Clinical Trials.

Digital assessment of muscle adaptation in obese patients with osteoarthritis: Insights from surface electromyography (sEMG).

Background: Obesity and severe knee osteoarthritis (KOA) lead to significant gait and muscle adaptations. However, the relationship between core muscle strength and the severity of KOA in obese patients remains unclear. This study aimed to determine the association between muscle strength adaptation and the severity of KOA in obese individuals.