Publications by authors named "Dietrich Lueerssen"
Introduction: A key factor in influenza pandemic preparedness is the ability to detect zoonotic influenza virus strains as they emerge in humans through spillover events, ideally before human-to-human transmission occurs.
Design: In this study, the utility of the QIAstat-Dx syndromic device for influenza surveillance was evaluated. Bioinformatic analysis was performed on all WHO-recommended influenza Candidate Vaccine Viruses (CVVs), including the common strains recommended for the 2023-2024 influenza vaccine composition in the northern hemisphere, and 16 different H5 highly pathogenic avian influenza virus (HPAIV) and two H9N2 low pathogenic avian influenza virus (LPAIV) strains.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is very rare, mainly found in the head and neck, with this case being the first in the fibula and only the eighth instance of occurrence in an extremity.
- A 2-month-old girl presented with a fibula mass; thorough testing revealed no mutations but identified a loss of function mutation in the CDKN2A gene, along with chromosomal translocations and gene fusions that may deregulate tumor-related microRNA genes.
- The findings suggest that MNTI's aggressive form in infants could stem from a genetic mutation combined with tumor-promoting gene fusions and epigenetic changes, highlighting the limited understanding of this rare tumor type