Inpatient treatment decreases depression but antidepressants may not contribute. A prospective quasi-experimental study.

Objective: The aim of the study is the evaluation of psychiatric-psychotherapeutic inpatient treatment utilizing a naturalistic design.

Methods: In a sample of 574 consecutively admitted patients, depression (64.5%), personality disorders (19.

Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation.

Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has robust 5-HT fibers and reciprocal connections with the hypothalamic-pituitary-adrenal (HPA) axis.