EFFECT OF LUBRICANTS ON CORNEAL THICKNESS AFTER VITRECTOMY.

Purpose: This study examines the impact of corneal surface lubricants used during pars plana vitrectomy on corneal edema.

Methods: This prospective, observational, clinical study occurred at an academic institution. Participants were individuals aged 18 years and older who had already consented to undergo pars plana vitrectomy, without pre-existing corneal pathology.

Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination.

: To report a case of Vogt-Koyanagi-Harada (VKH) disease associated with hepatitis B vaccination. : Case report. : A 43-year-old Caucasian male presented with a three-week history of blurry vision, pain, photophobia, and redness in both eyes.

Favorable Outcomes of Filamentous Fungal Endophthalmitis Following Aggressive Management.

Purpose: To evaluate the visual outcomes following aggressive management of filamentous fungal endophthalmitis with prompt surgical intervention and oral and intravitreal voriconazole.

Methods: Retrospective chart review study of consecutive patients with culture- or biopsy-proven filamentous fungal endophthalmitis treated at an academic referral center. Clinical characteristics, treatment regimens, and visual outcomes were analyzed.

Genetic ME-a visualization application for merging and editing pedigrees for genetic studies.

Background: In order to study the genetics of diseases more accurately and effectively, one often collects large families. Different members of a large family may provide differing information about the structure and make-up of their pedigree. Thus, software is needed to facilitate reconciliation of pedigrees collected independently from multiple informants from a single large family to create a unified pedigree that is based on the best composite information available.

Evidence for and against intravitreous corticosteroids in addition to intravitreous antibiotics for acute endophthalmitis.

The use of adjunctive intravitreous corticosteroids in endophthalmitis is controversial. Preclinical models showed that early administration of corticosteroids may be important although they reported mixed results in terms of their effects on antibiotic pharmacokinetics, control of infection and prevention of retinal damage. Most published retrospective clinical studies showed no beneficial effects associated with their use.

Functional and molecular characterization of CCK receptors in the rat pancreatic acinar cell line AR 4-2J.

Competitive inhibition binding studies on membranes from the rat pancreatic AR 4-2J cell line revealed the predominance (80%) of low selectivity CCK receptors (KD of 1 nM and 4 nM for, respectively, CCK-8 and gastrin-17I (G-17I] over selective receptors (20% with a KD of 1 nM and 1 microM for, respectively, CCK-8 and G-17I). Amylase secretion was stimulated by low concentrations of CCK-8, G-17I and CCK-4. G-17I-induced amylase secretion was unaffected by 100 nM of the selective peripheral CCK-A receptor antagonist L-364,718, suggesting that amylase hypersecretion followed non-selective CCK receptor activation, a function normally assumed by selective CCK-A receptors in rat pancreatic acini.