Publications by authors named "Diego da C Cabrera"
Article Synopsis
- The study aimed to investigate the calcium channel affinity and effects of 43 new lipophilic dihydropyridines, focusing on their antihypertensive and antioxidant properties, alongside toxicity testing compared to nifedipine.
- Animals with induced hypertension were treated for 56 days, first with N (ω) -nitro-L-arginine methyl ester and then with the dihydropyridines or nifedipine, with measurements taken for blood pressure, heart rate, and oxidative stress markers.
- The findings showed that two new dihydropyridines (2c and 9a) effectively lowered blood pressure and heart rate to normal levels, exhibiting superior antioxidant properties compared to nifedipine, indicating their
Polyhydroquinolines (PHQs) are the unsymmetrical Hantzsch derivatives of 1,4-dihydropyridines with several biological applications. In this work, new fatty 2- and 3-substituted PHQ derivatives from different fatty acids and fatty alcohol feedstocks were synthesized at good yields a four-component reaction (4CR). The antioxidant activities of fatty PHQs were investigated using three different antioxidant methods.
View Article and Find Full Text PDFThis work investigated the acute effects of the calcium channel blocker nifedipine and its new fatty hybrid derived from palmitic acid, 3,5-dipalmitoyl-nifedipine, compared to endocannabinoid anandamide during the process of inducing ischemia and reperfusion in cardiomyoblast H9c2 heart cells. The cardiomyoblasts were treated in 24 or 96-well plates (according to the test being performed) and maintaining the treatment until the end of hypoxia induction. The molecules were tested at concentrations of 10 and 100μM, cells were treated 24h after assembling the experimental plates and immediately before the I/R.
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