Cell cycle and protein complex dynamics in discovering signaling pathways.

Signaling pathways are responsible for the regulation of cell processes, such as monitoring the external environment, transmitting information across membranes, and making cell fate decisions. Given the increasing amount of biological data available and the recent discoveries showing that many diseases are related to the disruption of cellular signal transduction cascades, in silico discovery of signaling pathways in cell biology has become an active research topic in past years. However, reconstruction of signaling pathways remains a challenge mainly because of the need for systematic approaches for predicting causal relationships, like edge direction and activation/inhibition among interacting proteins in the signal flow.

Microservice-Oriented Platform for Internet of Big Data Analytics: A Proof of Concept.

The ubiquitous Internet of Things (IoT) devices nowadays are generating various and numerous data from everywhere at any time. Since it is not always necessary to centralize and analyze IoT data cumulatively (e.g.