Antimicrobial and antibiofilm activities of Brazilian organic honey against oral microorganisms.

Objective: To evaluate the antimicrobial activity of Brazilian honeys against oral microorganisms.

Design: Organic honeys (OH-1 to OH-8) were diluted (%-w/v) and sterilized by filtration. Antimicrobial activity was defined by determining MIC and CBM against oral Streptococcus.

Diacetylcurcumin: a novel strategy against biofilm in root canal disinfection.

We evaluated Diacetylcurcumin (DAC), a derivative of curcumin, for its antibacterial and antibiofilm properties against . Minimum inhibitory concentration (MIC) and minimum bactericidal concentration were determined, along with antibiofilm potential and toxicity in . Additionally, computational analysis was performed to understand its mechanisms of action.

Effects of gastric acid and mechanical toothbrushing in CAD-CAM restorative materials: Mechanical properties, surface topography, and biofilm adhesion.

Objective: To evaluate the effects of simulated gastric acid erosion combined with mechanical toothbrushing abrasion on the mechanical properties, surface topography, and biofilm adhesion of different CAD/CAM materials.

Material And Methods: Specimens of zirconia-reinforced lithium silicate glass-ceramic (ZLS), polymer-infiltrated ceramic network (PICN), feldspathic glass-ceramic (FE), and two nanoceramic resins (RK, RG), were submitted to the following challenges: erosion (E), abrasion (A), erosion combined with abrasion (E + A), or remained untreated (control - C). After challenges, flexural strength was evaluated, while microhardness (KHN) and surface roughness (Ra) were tested before and after treatments.

Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans: a study in vitro.

The aim of this research was to develop a chalcone-based endodontic irrigant for cleaning and disinfecting the root canal. Minimal inhibitory concentration (MIC) experiments in C. albicans and E.

A Study on the Anti-NF-κB, Anti-, and Antioxidant Activities of Two Natural Plant Hormones: Gibberellin A4 and A7.

Introduction: Gibberellins (GA) are terpenoids that serve as important plant hormones by acting as growth and response modulators against injuries and parasitism. In this study, we investigated the in vitro anti-NF-κB, anti-, and antioxidant activity of gibberellin A4 (GA4) and A7 (GA7) compounds, and further determined their toxicity in vivo.

Methods: GA4 and GA7 in vitro toxicity was determined by MTT method, and nontoxic concentrations were then tested to evaluate the GA4 and GA7 anti-NF-κB activity in LPS-activated RAW-luc macrophage cell culture (luminescence assay).

Brazilian Organic Honey from Atlantic Rainforest Decreases Inflammatory Process in Mice.

Honey is an ancient food in the human diet, and the chemical composition of some types of honey has been associated with several beneficial biological effects. Among them, honey has been highlighted to improve health and control inflammatory processes. However, there is no study elucidating the mechanism of action of honey produced organically.

Anti-inflammatory and anti- Effects of Brazilian Organic Propolis, a Promising Source of Bioactive Molecules and Functional Food.

Brazilian organic propolis (BOP) is an unexplored Brazilian propolis that is produced organically and certified according to international legislation. Our results showed that BOP has strong anti-inflammatory effects and acts by reducing nuclear factor κB activation, tumor necrosis factor α release, and neutrophil migration. In addition, BOP6 exhibited antifungal activity on planktonic and biofilm cultures of , , , , and and reduced yeast cell adhesion to human keratinocytes at sub-inhibitory concentrations.

Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action.

We evaluated the antifungal and antibiofilm potential of the hydroalcoholic extract of bark from Anadenanthera colubrina (vell.) Brenan, known as Angico, against Candida spp. Antifungal activity was evaluated using the microdilution technique through the Minimum Inhibitory and Fungicide Concentrations (MIC and MFC).

In silico approaches for screening molecular targets in Candida albicans: A proteomic insight into drug discovery and development.

Candida species are opportunistic pathogens which can cause conditions ranging from simple mucocutaneous infections to fungemia and death in immunosuppressed and hospitalized patients. Candida albicans is considered to be the species mostly associated with fungal infections in humans and, therefore, the mostly studied yeast. This microorganism has survival and virulence factors which, allied to a decreased host immunity response, make infection more difficult to control.

Candida auris: Epidemiology, risk factors, virulence, resistance, and therapeutic options.

Candida auris emerged as a pathogen resistant to multiple antifungal and has been associated with nosocomial outbreaks with high transmission capacity between hospitalized individuals. C. auris was first described in 2009, after being isolated from the external ear canal discharge of a patient in Japan.