Action of Varespladib (LY-315920), a Phospholipase A Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of (South-American Bushmaster) Venom.

Varespladib (VPL) was primarily developed to treat inflammatory disturbances associated with high levels of serum phospholipase A (PLA). VPL has also demonstrated to be a potential antivenom support agent to prevent PLA-dependent effects produced by snake venoms. In this study, we examined the action of VPL on the coagulant, haemorrhagic and enzymatic activities of (South-American bushmaster) venom.

A comparison of extradural tramadol and extradural morphine for postoperative analgesia in female dogs undergoing ovariohysterectomy.

Purpose: To compare the postoperative analgesic effects of the extradural tramadol or morphine in female dogs undergoing ovariohysterectomy.

Methods: Sixteen female dogs were randomly assigned to two groups of eight animals each and received morphine (0.1 mg kg(-1) M group) or tramadol (2 mg kg(-1) T group).

Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report.

Helicobacter pylori is a bacterium recognized as the major cause of peptic ulcer and chronic gastritis. Recently, a proteome-based approach was developed to investigate pathogenic factors related to H. pylori.