High-Intensity Intervallic Exercise (HIIE) Is Superior to Isocaloric Moderate-Intensity Continuous Exercise (MICE) at Reducing Postprandial Hyperglycemia.

Purpose: We investigated if a bout of HIIE is more efficacious at reducing postprandial hyperglycemia than an isocaloric bout of MICE.

Methods: Nineteen healthy physically active individuals (21% women) completed three trials in a randomized order: i) HIIE cycling consisting of 5 bouts of 4 min at 83 ± 9% of subjects' maximal oxygen consumption (V˙O2 MAX) with active recoveries at 53 ± 8% for a total of 50 min; ii) MICE cycling at 65 ± 8% of V˙O2 MAX for 50 min, and iii) CONTROL no exercise. All trials were followed by a standard oral glucose tolerance test (OGTT) ingesting 74 grams of glucose traced with 1 gram of uniformly labeled [13C]-glucose.

Clinical and physiological effects of high-intensity aerobic training on metabolic syndrome: understanding the individual exercise response variability.

We analyzed the interindividual heterogeneity in health responses to a supervised high-intensity interval training (HIIT) program in individuals with metabolic syndrome (MetS). Two hundred and sixty-four adults with overweight/obesity (56.3 ± 7.

Time-course atherogenic blood lipid response to statin discontinuation in dyslipidemic adults.

Background And Aims: Half of dyslipidemic patients sometimes discontinue statin medication. It is unclear if blood atherogenic risk increases right after statin discontinuation or if there is a lingering protective effect. We sought to determine if a legacy effect prevented blood lipid increases during the first stages of statin cessation.

A bout of aerobic exercise in the heat increases carbohydrate use but does not enhance the disposal of an oral glucose load, in healthy active individuals.

We investigated if a bout of exercise in a hot environment (HEAT) would reduce the postprandial hyperglycemia induced by glucose ingestion. The hypothesis was that HEAT stimulating carbohydrate oxidation and glycogen use would increase the disposal of an ingested glucose load [i.e.

Glucose volume of distribution affects insulin sensitivity measured by intravenous glucose tolerance test.

Aim: To determine whether glucose volume of distribution (Vd ) affects the diagnosis of impaired insulin sensitivity (IS) when using an intravenous glucose tolerance test (IVGTT).

Methods: Individuals with distinct levels of IS underwent IVGTT after an overnight fast. The prediabetic group (Prediab; n = 33) differed from the healthy group (Healthy; n = 14) in their larger glycosylated hemoglobin (HbA1c of 5.

Efficacy of morning versus afternoon aerobic exercise training on reducing metabolic syndrome components: A randomized controlled trial.

A supervised intense aerobic exercise program improves the health of individuals with metabolic syndrome (MetS). However, it is unclear whether the timing of training within the 24 h day would influence those health benefits. The present study aimed to determine the influence of morning vs.

Metformin and exercise effects on postprandial insulin sensitivity and glucose kinetics in pre-diabetic and diabetic adults.

The potential interaction between metformin and exercise on glucose-lowering effects remains controversial. We studied the separated and combined effects of metformin and/or exercise on fasting and postprandial insulin sensitivity in individuals with pre-diabetes and type 2 diabetes (T2D). Eight T2D adults (60 ± 4 yr) with overweight/obesity (32 ± 4 kg·m) under chronic metformin treatment (9 ± 6 yr; 1281 ± 524 mg·day) underwent four trials; ) taking their habitual metformin treatment (MET), ) substituting during 96 h their metformin medication by placebo (PLAC), ) placebo combined with 50 min bout of high-intensity interval exercise (PLAC + EX), and ) metformin combined with exercise (MET + EX).

Acute Statin Withdrawal Does not Interfere With the Improvements of a Session of Exercise in Postprandial Metabolism.

Background: The risk for atherogenic plaque formation is high after ingestion of meals in individuals with high blood lipid levels (ie, dyslipidemia). Statins and exercise reduce the rise of blood triglyceride concentrations after a meal, but the effect of their combination is unclear.

Methods: In a randomized crossover design, 11 individuals with dyslipidemia and metabolic syndrome treated with statins underwent a mixed-meal (970 ± 111 kcal, 24% fat, and 34% carbohydrate) tolerance test.