Publications by authors named "Diego Eduardo Alba"
Retinal microvascular and neuronal function in patients with multiple sclerosis: 2-year follow-up.
Mult Scler Relat Disord
November 2021
Objective: To determine the longitudinal changes in retinal microstructure, microvasculature, microcirculation, and axonal and neuronal functions in patients with relapsing-remitting multiple sclerosis (RRMS) over the time course of about two years.
Methods: A total of 30 patients (60 eyes) with RRMS were followed for a period of 27 ± 6 months and evaluated with a battery of clinical tests including low contrast letter acuity (LCLA), intraretinal layer thicknesses by optical coherence tomography (OCT), ganglion cell function by steady-state pattern electroretinography (PERG), axonal function by polarization-sensitive OCT, volumetric vessel density (VVD) by OCT angiography, and retinal tissue perfusion (RTP) by retinal function imager.
Results: Axonal function measured as retinal nerve fiber layer birefringence in the temporal quadrant and vessel density in the deep vascular plexus were significantly decreased at 2-year follow-up (P < 0.
Article Synopsis
- - This study aimed to analyze changes in the retina's structure, blood vessels, and function in patients with relapsing-remitting multiple sclerosis (RRMS) over one year.
- - A total of 44 patients underwent various tests both at the start and after one year, with findings showing significant decreases in axonal birefringence and increases in retinal tissue perfusion, particularly in patients with a history of optic neuritis.
- - The results suggest that retinal vascular changes could serve as potential biomarkers for tracking treatment effectiveness in MS and are linked to disease progression.