Comparison of psychodrug prescription patterns in patients diagnosed with bipolar disorder and addiction.

Objective: To describe if there are differences in the prescription of psychodrug at discharge between bipolar disorder patients with or without addiction.

Methods: We review all the psychotropic drugs dispensed to inpatients of a brief hospitalization psychiatric unit diagnosed as having bipolar disorder at time of discharge. We recluted 225 patients over 18 years old on their last manic episode, between the year 2000 and 2010.

Relative abuse liability of gamma-hydroxybutyric acid, flunitrazepam, and ethanol in club drug users.

Objectives: Despite the increasing concern about gamma-hydroxybutyric acid (GHB) toxicity, there are few studies examining the clinical pharmacology of GHB and its abuse potential. To evaluate GHB-induced subjective and physiological effects, its relative abuse liability and its impact on psychomotor performance in club drug users.

Materials And Methods: Twelve healthy male recreational users of GHB participated in 5 experimental sessions in the framework of a clinical trial.

Relationship of abdominal obesity with alcohol consumption at population scale.

Background: The high energy content of alcohol makes its consumption a potential contributor to the obesity epidemic.

Aim Of The Study: To determine whether alcohol consumption is a risk factor for abdominal obesity, taking into account energy underreporting.

Methods: The subjects were Spanish men (n = 1491) and women (n = 1563) aged 25-74 years who were examined in 1999-2000, in a population-based cross-sectional survey in northeastern Spain (Girona).

Gamma-hydroxybutyrate (GHB) in humans: pharmacodynamics and pharmacokinetics.

Despite gamma-hydroxybutyrate (GHB) therapeutic uses and the increasing concern about its toxicity, few studies have addressed GHB dose-related effects under controlled administration and their relationship with its pharmacokinetics. The study design was double-blind, randomized, crossover, and controlled. As a pilot pharmacology phase I study, increasing doses of GHB were given.