Publications by authors named "Diego Asensio-Wandosel"
Aim: To investigate the impact of pituitary surgery on glucose metabolism and to identify predictors of remission of diabetes after pituitary surgery in patients with acromegaly.
Methods: A national multicenter retrospective study of patients with acromegaly undergoing transsphenoidal surgery for the first time at 33 tertiary Spanish hospitals (ACRO-SPAIN study) was performed. Surgical remission of acromegaly was evaluated according to the 2000 and 2010 criteria.
Objective: The aim of this study is to compare the response to first-line medical treatment in treatment-naive acromegaly patients with pure growth hormone (GH)-secreting pituitary adenoma (GH-PA) and those with GH and prolactin cosecreting PA (GH&PRL-PA).
Design: This is a retrospective multicentric study of acromegaly patients followed from 2003 to 2023 in 33 tertiary Spanish hospitals with at least 6 months of first-line medical treatment.
Methods: Baseline characteristics, first-line medical treatment strategies, and outcomes were analyzed.
Article Synopsis
- A study evaluated the differences in clinical presentation and surgical outcomes between two types of pituitary adenomas: growth hormone secreting (GH-PAs) and those that cosecrete growth hormone and prolactin (GH&PRL-PAs).
- GH&PRL-PAs were found to occur more frequently as macroadenomas, had a lower average age at diagnosis, and were more likely to show signs of invasiveness and hypopituitarism compared to GH-PAs.
- Despite these differences in presentation, both groups had similar rates of surgical success in terms of biochemical cure, although GH&PRL-PA patients experienced a higher incidence of permanent arginine-vasopressin deficiency