Clinical Manifestations.

Background: Families with a history of Alzheimer's Disease (AD) may have a genetic predisposition that raises the risk of developing the condition. However, not all members of these families can undergo genetic testing. Thus, this study aims to evaluate specific cognitive changes, neuropsychiatric symptoms (NPS), and personality traits that may act as early indicators of AD in family members compared to controls.

Neuropsychiatric symptoms as a prodromal factor in Alzheimer's type neurodegenerative disease: A scoping review.

Identifying neuropsychiatric symptoms (NPS) can aid in the early detection of Alzheimer's disease (AD); however, there is still a need for a greater consensus. This review aims to delineate the predominant NPS, compile a comprehensive list of the most commonly employed NPS assessment tools, and corroborate the principal findings regarding the link between NPS and neuropsychological assessment and neurobiological substrates. To conduct this scoping review, we followed the Preferred Reporting Items for Systematic Reviews guidelines and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR).