Publications by authors named "Diego A Morales-Scheihing"
Background: Sex differences in COVID-19 are increasingly recognized globally. Although infection rates are similar between the sexes, men have more severe illness. The mechanism underlying these sex differences is unknown, but a differential immune response to COVID-19 has been implicated in several recent studies.
View Article and Find Full Text PDFThe role of oxytocin (OT) in social cognition of patients with Huntington's disease (HD) has been studied, but its impact on executive functioning has not been explored yet. Healthy controls, premanifest HD, and manifest HD participants underwent executive functioning assessment and OT plasma measurement. There were no significant group differences in plasma OT levels.
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- Guanine-rich DNA sequences can form four-stranded structures called G-quadruplexes (G4-DNA), which play a role in regulating key cellular processes like replication and transcription, especially in cancer cells.
- Research shows that stabilizing G4-DNA in neurons using specific ligands can lead to decreased expression of a crucial gene involved in autophagy, which declines with age.
- In experiments, aging mice exhibited increased G4-DNA structures in their brains compared to younger mice, and enhancing the levels of a G4-DNA helicase improved the negative effects caused by G4-DNA stabilization on memory.