Publications by authors named "Diego A C P G Mello"
() is a Gram-positive bacterium that causes infections ranging from mild superficial cases to more severe, potentially fatal conditions. Many photosensitisers used in photodynamic therapy are more effective against superficial infections due to limitations in treating deeper tissue infections. Recently, attention to this bacterium has increased due to the emergence of multidrug-resistant strains, which complicate antibiotic treatment.
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- Lung transplantation is often necessary for severe lung diseases, but the success rates are low, making lung bioengineering a potential alternative using decellularized lung extracellular matrix (ECM).
- The study focused on improving lung recellularization by seeding decellularized lungs with mesenchymal stem cells and applying photobiomodulation therapy (PBMT) at two different wavelengths (660 nm for recellularization and 880 nm for sterilization).
- Results showed that PBMT helped maintain important structural components of the lungs and modulated pro-inflammatory cytokines, indicating its potential to enhance therapeutic strategies in lung bioengineering.
Article Synopsis
- - Chronic respiratory diseases can lead to irreversible lung damage, making lung transplantation necessary, and organ engineering with stem cells shows promise for generating new organs.
- - This study systematically reviewed literature on decellularised lungs' extracellular matrix (ECM) conditions after various sterilisation processes, following PRISMA guidelines and analyzing five positive-result articles.
- - The findings indicate that all sterilisation methods, whether physical or chemical, negatively impact the ECM, and no ideal sterilisation protocol was identified for effective pulmonary scaffold preparation in tissue or organ engineering.
Frailty is a state of critical loss of physiological complexity resulting in greater vulnerability to stressors and has been characterized as a debility syndrome in the older adult. Changes in functional capacity and the cardiovascular system during aging are the most significant and relevant for this population, including the clinically healthy. In this sense, this review aims to investigate methods to monitor the performance of older adults, such as heart rate variability and verify how it can be related to frailty.
View Article and Find Full Text PDFAsthma is the most common inflammatory disease affecting the lungs, which can be caused by intrauterine or postnatal insults depending on the exposure to environmental factors. During early life, the exposure to different risk factors can influence the microbiome leading to undesired changes to the immune system. The modulations of the immunity, caused by dysbiosis during development, can increase the susceptibility to allergic diseases.
View Article and Find Full Text PDFAsthma is a widespread disease characterized by chronic airway inflammation. It causes substantial disability, impaired quality of life, and avoidable deaths around the world. The main treatment for asthmatic patients is the administration of corticosteroids, which improves the quality of life; however, prolonged use of corticosteroids interferes with extracellular matrix elements.
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