Fully Reprogrammable 2D Array of Multistate Molecular Switching Units.

Integration of molecular switching units into complex electronic circuits is considered to be the next step toward the realization of novel logic and memory devices. This paper reports on an ordered 2D network of neighboring ternary switching units represented by triazatruxene (TAT) molecules organized in a honeycomb lattice on a Ag(111) surface. Using low-temperature scanning tunneling microscopy, the bonding configurations of individual TAT molecules can be controlled, realizing up to 12 distinct states per molecule.

Evaluation of vaginal microbiome equilibrium states identifies microbial parameters linked to resilience after menses and antibiotic therapy.

The vaginal microbiome (VMB) is a complex microbial community that is closely tied to reproductive health. Optimal VMB communities have compositions that are commonly defined by the dominance of certain Lactobacillus spp. and can remain stable over time or transition to non-optimal states dominated by anaerobic bacteria and associated with bacterial vaginosis (BV).

Prevalence and Characterization of Escherichia coli O157:H7 on Pork Carcasses and in Swine Colon Contents from Provincially Licensed Abattoirs in Alberta, Canada.

Abstract: The objective of this study was to determine the prevalence of Shiga toxin-producing Escherichia coli (STEC) O157:H7 in colon contents and on carcasses from pigs slaughtered at provincially licensed abattoirs (PLAs) in Alberta, Canada. In 2017, carcass sponge samples and colon content samples were collected from 504 healthy market hogs at 39 PLAs and analyzed for E. coli O157:H7.

Tip-Induced Inversion of the Chirality of a Molecule's Adsorption Potential Probed by the Switching Directionality.

The switching behavior of surface-supported molecular units excited by current, light, or mechanical forces is determined by the shape of the adsorption potential. The ability to tailor the energy landscape in which a molecule resides at a surface gives the possibility of imposing a desired response, which is of paramount importance for the realization of molecular electronic units. Here, by means of scanning tunneling microscopy, a triazatruxene (TAT) molecule on Ag(111) is studied, which shows a switching behavior characterized by transitions of the molecule between three states, and which is attributed to three energetically degenerate bonding configurations.

Amblyopia Elimination Project: Pediatric Medical Home-Based Community Vision Screening.

Purpose: To examine whether facilitating access to instrument-based screening equipment will increase the total number of high-quality, age-appropriate vision screenings provided to the preschool aged population.

Methods: The goal of the Naples Lions Amblyopia Elimination Project was to place a SPOT Vision Screener (Welch Allyn, Skaneateles Falls, NY) in every pediatric medical home using philanthropic dollars. Participating medical homes agreed to provide data on the number of children screened, number of referrals made, criteria for referral, and follow-up notes regarding examination outcomes.

Membrane transporters studied by EPR spectroscopy: structure determination and elucidation of functional dynamics.

During their mechanistic cycles membrane transporters often undergo extensive conformational changes, sampling a range of orientations, in order to complete their function. Such membrane transporters present somewhat of a challenge to conventional structural studies; indeed, crystallization of membrane-associated proteins sometimes require conditions that vary vastly from their native environments. Moreover, this technique currently only allows for visualization of single selected conformations during any one experiment.

Managing advanced illness.

Every organization can deliver patient-centered end-of-life care.

The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing.

Myotonic dystrophy type 1 (DM1) is a genetic disorder linked to a (CTG)(n) repeat expansion in the 3' untranslated region of the DMPK gene. Upon transcription in the nucleus, the CUG repeats form a stable RNA stem-loop that sequesters the RNA-binding protein MBNL1 from its normal function in the cell. MBNL1 regulates the alternative splicing of many pre-mRNAs, and upon MBNL1's sequestration, the alternative splicing of many genes is mis-regulated, leading to disease symptoms.

Improved maternal and child health care access in a rural community.

Few studies have measured the extent to which expansion of health services for pregnant women and children in poor rural communities improves access to care and health status. This paper describes an underserved rural community in which health care initiatives increased access to comprehensive care. Over a three-year period, use of preventive services increased, whereas emergency room visits and hospitalizations at the community hospital decreased.

Calcium dependence of prostaglandin release from the guinea pig Taenia coli.

We studied the calcium dependency of the stimulation of prostaglandin synthesis which occurs when perfusing strips of guinea pig Taenia coli with potassium-free media. Stimulation was rapidly reversed by removal of extracellular Ca from the bathing solution. The Ca ionophore A23187 markedly stimulated prostaglandin E2 synthesis, an effect that is dependent on the presence of extracellular Ca.

Origin of the nonexponentiality of the water proton spin relaxations in tissues.

An attempt to explain the nonexponential recovery of the water proton spin magnetization in tissues is presented. The origin of this effect is the nonhomogeneity of the material and the distribution of slow diffusion correlation times. This proposal is based on a dispersion study of the tissue water proton spin relaxation time in the rotating frame.

A possible improvement in the resolution of proton spin relaxation for the study of cancer at low frequency.

Available results indicate that the water proton spin-lattice relaxation time resolution, defined as [T1(tumorous) -T1(healthy)]/T1(tumorous), may increase if relaxation time is measured at 2 rather than at 30 MHz.