Open-mindedness: An integrative review of interventions.

Partisan animosity has been growing in the United States and around the world over the past few decades, fueling efforts by researchers and practitioners to help heal the divide. Many studies have been conducted to test interventions that aim to promote open-mindedness; however, these studies have been conducted in disparate literatures that do not always use the same terminology. In this review, we integrate research on open-mindedness in order to facilitate cross-talk and collaboration between disciplines.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization.

Unlabelled: Microenvironment niches determine cellular fates of metastatic cancer cells. However, robust and unbiased approaches to identify niche components and their molecular profiles are lacking. We established Sortase A-Based Microenvironment Niche Tagging (SAMENT), which selectively labels cells encountered by cancer cells during metastatic colonization.

Default egocentrism: an MVPA approach to overlap in own and others' socio-political attitudes.

Understanding the socio-political attitudes of other people is a crucial skill, yet the neural mechanisms supporting this capacity remain understudied. This study used multivariate pattern analysis to examine patterns of activity in the default mode network (DMN) while participants assessed their own attitudes and the attitudes of other people. Classification analyses indicated that common patterns in DMN regions encode both own and others' support across a variety of contemporary socio-political issues.

Sleep duration moderates the associations between immune markers and corticolimbic function during stress in adolescents.

Adolescence is characterized by biological changes in hormonal and circadian systems that, with concurrent psychosocial changes, result in increased sleep disturbances and stress sensitivity. Sleep disturbance has been associated with heightened stress sensitivity and elevated levels of inflammation in adults and adolescents, yet the neural correlates are unknown in adolescents. The current study investigated whether and how individual differences in peripheral immune markers (IL-6, TNF-α) related to neural response to stress in adolescents and whether these immune-brain associations were moderated by adolescents' sleep duration.

The Zoom solution: Promoting effective cross-ideological communication online.

The rise of ideological polarization in the U.S. over the past few decades has come with an increase in hostility on both sides of the political aisle.

Giving to others and neural processing during adolescence.

Adolescence is marked by an increased sensitivity to the social environment as youth navigate evolving relationships with family, friends, and communities. Prosocial behavior becomes more differentiated such that older adolescents increasingly give more to known others (e.g.

The comfort in touch: Immediate and lasting effects of handholding on emotional pain.

Consoling touch is a powerful form of social support that has been repeatedly demonstrated to reduce the experience of physical pain. However, it remains unknown whether touch reduces emotional pain in the same way that it reduces physical pain. The present research sought to understand how handholding with a romantic partner shapes experiences of emotional pain and comfort during emotional recollection, as well as how it shapes lasting emotional pain associated with emotional experiences.

Neural reference groups: a synchrony-based classification approach for predicting attitudes using fNIRS.

Social neuroscience research has demonstrated that those who are like-minded are also 'like-brained.' Studies have shown that people who share similar viewpoints have greater neural synchrony with one another, and less synchrony with people who 'see things differently.' Although these effects have been demonstrated at the 'group level,' little work has been done to predict the viewpoints of specific 'individuals' using neural synchrony measures.

Mechanisms of Resistance to Immunotoxins Containing Exotoxin A in Cancer Therapy.

Immunotoxins are a class of targeted cancer therapeutics in which a toxin such as exotoxin A (PE) is linked to an antibody or cytokine to direct the toxin to a target on cancer cells. While a variety of PE-based immunotoxins have been developed and a few have demonstrated promising clinical and preclinical results, cancer cells frequently have or develop resistance to these immunotoxins. This review presents our current understanding of the mechanism of action of PE-based immunotoxins and discusses cellular mechanisms of resistance that interfere with various steps of the pathway.

Moving a hospital information system towards a client server architecture.

This paper is intended to give you an overview about the migration process of the Hospital Information System (HIS) at the University Hospital of Giessen towards an open client server based architecture. It describes the software architecture of the existing mainframe applications and the network interfaces involved in opening the centralized software architecture to a wide variety of remote applications.