The First Case of Felty's Syndrome Complicated by COVID-19 Infection.

Felty's syndrome (FS) is an uncommon disorder with a poor prognosis, and most patients die from infections caused by neutropenia. Currently, there is no standardized treatment strategy, and treatment options are based on case reports and clinical experience. To date, no cases of FS complicated by coronavirus disease-2019 (COVID-19) have been reported.

F-box protein PeFKF1 promotes flowering by cooperating with PeID1 and PeHd1 in Phyllostachys edulis.

Woody bamboo is a perennial flowering plant with a unique characteristic. Most woody bamboo species have no apparent signs before flowering, and large areas typically die after flowering, thus resulting in significant economic losses. However, most bamboo flowering gene functions and molecular mechanisms are still unclear.

Causal effects of pediatric asthma on psychiatric disorders: a bidirectional Mendelian randomization study.

Background: Previous studies have suggested a potential link between pediatric asthma and psychiatric disorders. However, the causal relationship between pediatric asthma and psychiatric disorders is unclear. Therefore, we used Mendelian randomization to explore causal relationships between pediatric asthma and depression, anxiety disorders, and attention deficit and hyperactivity disorder (ADHD).

Integrated interferometers as a new platform for low cost gas chromatography detection.

Gas chromatography is a reference method for gas analysis. As part of efforts to miniaturize gas chromatography systems, the miniaturization of detectors is essential. In this work, we report a new integrated photonic platform for gas chromatography analyte detection.

Immunological profiling for short-term predictive analysis in PD-1/PD-L1 therapy for lung cancer.

Background: Immune checkpoint inhibitors, such as anti-programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1) antibodies, have achieved breakthrough results in improving long-term survival rates in lung cancer. Although high levels of PD-L1 expression and tumor mutational burden have emerged as pivotal biomarkers, not all patients derive lasting benefits, and resistance to immune checkpoint blockade remains a prevalent issue. Comprehending the immunological intricacies of lung cancer is crucial for uncovering the mechanisms that govern responses and resistance to immunomodulatory treatments.

Machine Learning for Early Discrimination Between Lung Cancer and Benign Nodules Using Routine Clinical and Laboratory Data.

Background: Lung cancer poses a global health threat necessitating early detection and precise staging for improved patient outcomes. This study focuses on developing and validating a machine learning-based risk model for early lung cancer screening and staging, using routine clinical data.

Methods: Two medical center, observational, retrospective studies were conducted, involving 2312 lung cancer patients and 653 patients with benign nodules.

The antibodies against the A137R protein drive antibody-dependent enhancement of African swine fever virus infection in porcine alveolar macrophages.

African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a highly contagious disease that can kill up to 100% of domestic pigs and wild boars. It has been shown that the pigs inoculated with some ASF vaccine candidates display more severe clinical signs and die earlier than do pigs not immunized. We hypothesize that antibody-dependent enhancement (ADE) of ASFV infection may be caused by the presence of some unidentified antibodies.

Realizing long-term cycling stability of O3-type layered oxide cathodes for sodium-ion batteries.

O3-type layered oxide cathodes are promising for practical sodium-ion batteries (SIBs) owing to their high theoretical capacity, facile synthesis, and sufficient Na storage. However, they face challenges such as rapid capacity loss and poor cycling stability, mainly attributed to irreversible phase transitions. To address these challenges, a novel cathode material, Li/Sn co-substituted O3-NaLiSnNiFeMnO (LSNFM), has been designed by regulating the electronic structure, in which Li activates more redox reactions of Ni and Fe above 2.

CEBPA mutations in acute myeloid leukemia: implications in risk stratification and treatment.

Mutations in CCAAT enhancer binding protein α (CEBPA) occur in approximately 10% of patients with de novo acute myeloid leukemia (AML). Emerging evidence supports that in-frame mutations in the basic leucine zipper domain of CEBPA (CEBPA) confer a survival benefit, and CEBPA replaced CEBPA double mutations (CEBPA) as a unique entity in the 2022 World Health Organization (WHO-2022) classification and International Consensus Classification (ICC). However, challenges remain in daily clinical practice since more than 30% patients with CEBPA die of AML despite intensive treatment.

Clinical characteristics and influence of postoperative Hirschsprung-associated enterocolitis: retrospective study at a tertiary children's hospital.

Purpose: To explore the influence of postoperative Hirschsprung-associated enterocolitis (post-HAEC) on long-term outcomes and to identify risk factors of post-HAEC.

Methods: The medical records of 304 eligible patients diagnosed with Hirschsprung's disease (HSCR) were reviewed. We analyzed the clinical characteristics of post-HAEC and its influence on long-term outcomes.

Transanal fistula repair for the treatment of rectovestibular fistula with normal anus in female children: a 5-year single-center experience.

Purpose: The purpose of this study was to review a 5-year operative experience of transanal fistula repair for the treatment of rectovestibular fistula with a normal anus in female children.

Methods: In this study, we conducted a retrospective review of children diagnosed with rectovestibular fistula with normal anus who underwent transanal fistula repair in the department of General Surgery, Children's Hospital of Chongqing Medical University. Clinical data were retrospectively analyzed.

Intelligent health and sport: An interplay between flexible sensors and basketball.

Basketball, as one of the most popular sports in the world, has millions of followers and massive economic value. Basketball evolves so fast that it requires teams with smarter strategies, better skills, and stronger players. However, the competition strategies and training methods in basketball are still experience-based, lacking precise data to drive for more efficient training and strategies.

Wearable and interactive multicolored photochromic fiber display.

Endowing flexible and adaptable fiber devices with light-emitting capabilities has the potential to revolutionize the current design philosophy of intelligent, wearable interactive devices. However, significant challenges remain in developing fiber devices when it comes to achieving uniform and customizable light effects while utilizing lightweight hardware. Here, we introduce a mass-produced, wearable, and interactive photochromic fiber that provides uniform multicolored light control.

Sex-determining region Y gene promotes liver fibrosis and accounts for sexual dimorphism in its pathophysiology.

Background & Aims: Men are more prone to develop and die from liver fibrosis than women. In this study, we aim to investigate how sex-determining region Y gene (SRY) in hepatocytes promotes liver fibrosis.

Methods: Hepatocyte-specific Sry knock-in (KI), Sry knockout (KO), and Sry KI with platelet-derived growth factor receptor α (Pdgfrα) KO mice were generated.

Clinical characteristics of congenital heart defects in mild congenital anorectal malformation: single-centre experience.

Objective: To analyze the clinical characteristics and types of congenital heart defect (CHD) in mild congenital anorectal malformation (CARM), namely the rectoperineal and rectovestibular fistulas.

Methods: The retrospective study of 183 patients with mild CARM was conducted with assessments of demographic information, color Doppler echocardiography results, and follow-up data. We performed an analysis of the clinical characteristics of CHD, grouping them based on sex and type of mild CARM.

Applications of indocyanine greenenhanced fluorescence in the laparoscopic treatment of colonic stricture after necrotizing enterocolitis.

Background: The status of anastomotic blood perfusion is associated with the occurrence of anastomotic leakage after intestinal anastomosis. Fluorescence angiography (FA) with indocyanine green (ICG) can objectively assess intestinal blood perfusion. This study aims to investigate whether anastomotic perfusion assessment with ICG influences surgical decision-making during laparoscopic intestinal resection and primary anastomosis for colonic stricture after necrotizing enterocolitis.

Modeling and Experimental Investigation of U-R Relationship of AA6061-T6 Tubes Manufactured via Free Bending Forming Process.

Forming tubes with various bending radii without changing the bending dies is much easier for the 3D free bending forming (FBF) process. In the 3D-FBF process, different bending radii were realized by adapting the eccentricities of the bending dies. The accuracy of the curve is crucial for the precision forming of complex bending components.

Constructing P2/O3 biphasic structure of Fe/Mn-based layered oxide cathode for high-performance sodium-ion batteries.

Fe/Mn-based layered oxide cathode is regarded as a competitive candidate for sodium-ion batteries (SIBs) because of its high theoretical capacity, earth abundance and low cost. However, its poor cycling stability still remains a major bottleneck. Herein, P2/O3 biphasic NaFeMnCuO layered oxide is successfully synthesized via a sol-gel method.

Effect of Scanning Strategy on the Microstructure and Triboperformance of FeNiCrMo Coating Manufactured by Plasma Transferred Arc.

To increase the coating thickness and service life of the FeNiCrMo coating, a plasma transferred arc (PTA) double-track alloying technique was employed to enhance the surface triboperformance of the ductile iron. Optical microscopy (OM), X-ray diffraction (XRD), electron probe X-ray microanalyzer (EPMA), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Vickers hardness tester, and tribological tester were subsequently used to evaluate the effect of the double alloying treatment tracks on the microstructure and triboperformance of the coating. The results indicate that the content of the cementite in the sample with a double-track treatment increases 3.

Controllable-morphology polymer blend photonic metafoam for radiative cooling.

Incorporating radiative cooling photonic structures into the cooling systems of buildings presents a novel strategy to mitigate global warming and boost global carbon neutrality. Photonic structures with excellent solar reflection and thermal emission can be obtained by a rational combination of different materials. The current preparation strategies of radiative cooling materials are dominated by doping inorganic micro-nano particles into polymers, which usually possess insufficient solar reflectance.

Effects of Dihuang Yinzi Decoction on Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Objective: The aim of this study was to systematically evaluate the therapeutic effects of Dihuang Yinzi decoction on Alzheimer's disease (AD) and provide a medical evidence-based clinical application of traditional Chinese medicine (TCM).

Methods: A comprehensive search was conducted across multiple databases, including PubMed, Embase, Cochrane Library, China National Journals Full-text Database, VIP Database for Chinese Technical Periodicals, Wan Fang database, and SinoMed database, to collect clinical randomized controlled trials of Dihuang Yinzi decoction in the treatment of AD. Strict literature screening was performed based on predefined inclusion and exclusion criteria.