Amatoxin poisoning treatment decision-making: pharmaco-therapeutic clinical strategy assessment using multidimensional multivariate statistic analysis.

Ninety percent of fatal higher fungus poisoning is due to amatoxin-containing mushroom species. In addition to absence of antidote, no chemotherapeutic consensus was reported. The aim of the present study is to perform a retrospective multidimensional multivariate statistic analysis of 2110 amatoxin poisoning clinical cases, in order to optimize therapeutic decision-making.

Amanita muscaria: chemistry, biology, toxicology, and ethnomycology.

The fly agaric is a remarkable mushroom in many respects; these are its bearing, history, chemical components and the poisoning that it provokes when consumed. The 'pantherina' poisoning syndrome is characterized by central nervous system dysfunction. The main species responsible are Amanita muscaria and A.

Facile protection of phenols and hydroxypyridines: key components of natural products--a new pathway to orellanine.

The (1,3,6-trioxa-heptyl) aromatic compounds are easily prepared from various phenols and hydroxypyridines. Protection by 2-methoxyethoxymethyl chloride (MEM-Cl) was achieved by phase transfer catalysis with Aliquat 336, subsequent removal of the protecting group was completed with Amberlyst 15. The 2-bromo-3-hydroxy-pyridine 3o constitutes the appropriate starting material for the synthesis of orellanine, the most potent nephrotoxin found in some Cortinarius mushrooms species.