Sphaerococcenol A Derivatives: Design, Synthesis, and Cytotoxicity.

Sphaerococcenol A is a cytotoxic bromoditerpene biosynthesized by the red alga . A series of its analogues (-) was designed and semi-synthesized using thiol-Michael additions and enone reduction, and the structures of these analogues were characterized by spectroscopic methods. Cytotoxic analyses (1-100 µM; 24 h) were accomplished on A549, DU-145, and MCF-7 cells.