Publications by authors named "Didem Aydin"

Objective: This study investigated the effects of sleep deprivation (SD) on balance after normal sleep, 24 h of SD, and subsequent rest under eyes-open (EO) and eyes-closed (EC) conditions. Our aim was to ascertain whether the reduced efficiency of balance control following SD is generalized or selective.

Method: Nineteen participants (12 females, 7 males) completed the Pittsburgh Sleep Quality Index (PSQI).

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In the search of novel photocatalysts to increase the effect of visible light in photocatalysis, g-CN (CN) has become a shining star. Rare earth metals have been used as dopant material to reinforce the photocatalytic activity of CN due to their unique electron configuration recently. In this present study, the pure and different amounts of Ho-doped g-CN (HoCN) photocatalysts were successfully synthesized using urea as a precursor by the one-pot method.

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In recent years, water pollution caused by hazardous materials such as metals, drugs, pesticides, and insecticides has become a very serious environmental and health problem that needs to be addressed urgently. The nutritional needs associated with the increasing population also increase the demand for water use and rapidly increase the rate of freshwater consumption. Since most of the water in the universe is in the form of sea water, which cannot be directly used, freshwater resources are limited, compared to the existing available water.

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Article Synopsis
  • - In the MagnetisMM-3 trial, the efficacy of elranatamab was compared to physician's choice treatment for patients with triple-class refractory multiple myeloma, showing promising results for the new therapy.
  • - Analysis of two oncology databases (COTA and Flatiron Health) revealed that patients treated with elranatamab had a higher objective response rate, longer progression-free survival, and better overall survival compared to those receiving standard physician-selected treatments.
  • - Elranatamab demonstrated significant benefits for BCMA-naive patients, suggesting it may be a more effective option compared to treatments commonly used in clinical practice.
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Article Synopsis
  • For patients with triple-class exposed/refractory multiple myeloma (TCE/RMM), B-cell maturation antigen and CD3-directed bispecific antibodies like teclistamab and elranatamab are emerging as new treatment options due to limited existing therapies.
  • Teclistamab received conditional approval in Europe and accelerated FDA approval based on the MajesTEC-1 trial, while elranatamab was approved by the FDA following the MagnetisMM-3 trial.
  • An indirect comparison showed that elranatamab outperformed teclistamab in terms of objective response rate and progression-free survival, suggesting it may be a more effective treatment for TCE/RMM patients.
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Aim: Formaldehyde is a chemical that lies behind the various systemical failures in organism. Many products that people use contain formaldehyde. Owing to its tissue fixative properties, scientists who work in life sciences are exposed to this substance more than others.

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Article Synopsis
  • - Elranatamab, a new bispecific antibody targeting BCMA and CD3, was approved in August 2023 for treating triple-class exposed/refractory multiple myeloma (TCE/R MM) and showed promising results in the Phase 2 MagnetisMM-3 trial.
  • - A matching-adjusted indirect comparison (MAIC) was conducted to evaluate elranatamab's effectiveness against physician's choice of treatment (PCT) by adjusting patient data from MagnetisMM-3 to real-world data from LocoMMotion and MAMMOTH studies.
  • - Results indicated elranatamab significantly outperformed PCT, showing higher objective response rates, complete response rates, and longer
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There are disparities in outcomes for patients with multiple myeloma (MM). We evaluated the influence of sociodemographic factors on global disparities in outcomes for patients with MM. This rapid evidence assessment (PROSPERO, CRD42021248461) followed PRISMA-P guidelines and used the PICOS framework.

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Objective: Etiological evaluation of the patients who were hospitalized with the diagnosis of severe anemia (Hb<7 gr/dl) in the emergency internal medicine clinic between January and July, 2013.

Methods: In this study, 112 patients who were hospitalized in Dr. Lutfi Kirdar Kartal Education and Research Hospital emergency internal medicine clinic with severe anemia between January and July 2013 were retrospectively analyzed.

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Concentrations of Mn, Fe, Co, Ni, As, Se, Cd, Ag and Pb in scale, skin, muscle, gills, liver and the gonads of Gilthead seabream (Sparus aurata), European seabass (Dicentrarchus labrax), Black Sea salmon (Salmo trutta labrax), Horse mackerel (Trachurus trachurus), Red mullet (Mullus barbatus) and Whiting (Merlangius merlangius euxinus) from the Black Sea, in Turkey, were investigated. Elemental analyses were performed with inductively coupled plasma-mass spectrometry after sample preparation by microwave digestion. Mean metal concentrations in different tissues were in the following ranges: Mn 0.

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Statement Of Problem: The development of computer-aided design/computer-aided manufacturing technology has enabled the fabrication of implant-retained restorations. However, information on the marginal and axial accuracy of restorations fabricated by different digitizing techniques with different antirotational abutment features is not sufficient.

Purpose: The purpose of this in vitro study was to evaluate the influence of digitizing techniques on the fit of implant-retained crowns with 2 antirotational features.

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Cell-surface CD25 expression is critical for maintaining immune function and homeostasis. As in few reported cases, CD25 deficiency manifests with severe autoimmune enteritis and viral infections. To dissect the underlying immunological mechanisms driving these symptoms, we analyzed the regulatory and effector T cell functions in a CD25 deficient patient harboring a novel IL2RA mutation.

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The aim of this study was to comparatively investigate the effects of 5-azacytidine-C (5-Aza), trichostatin-A (TSA), and all-trans retinoic acid (ATRA) on the mRNA expressions of the sodium and iodine (Na/I) symporter (NIS), thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyroid-stimulating hormone receptor (TSH-R), as well as radioiodine (RAI) uptake in cancer (B-CPAP) and normal (Nthy-ori 3-1) thyroid cell lines. Cell lines were treated with 10 ng/mL of TSA, 5 microM of 5-AZA, and 1 microM of ATRA, according to the MTT (methyl-thiazol-tetrazolium) test results. Additionally, recombinant thyroid-stimulating hormone (rTSH) was also applied, with a selected dose of 100 ng/mL.

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The aim of this study was to comparatively investigate the effects of 5-azacytidine-C (5-Aza), trichostatin-A (TSA), and all-trans retinoic acid (ATRA) on mRNA expressions of Na/I symporter (NIS), thyroglobulin (Tg), thyroid peroxidase (TPO), and thyroid stimulating hormone receptor (TSH-R), and radioiodine (RAI) uptake in cancer (B-CPAP) and normal (Nthy-ori 3-1) thyroid cell lines. Cell lines were treated with 10 ng/mL of TSA, 5 microM of 5-Aza, and 1 microM of ATRA, according to the MTT (methyl-thiazol-tetrazolium) test results. Additionally, recombinant thyroid stimulating hormone (rTSH) was also applied, with a selected dose of 100 ng/mL.

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