Publications by authors named "Didac LLop"
Backgrounds And Aims: Preclinical studies suggest that a triglyceride (TG)-independent proinflammatory action of apolipoprotein C-III (apoCIII) exists. We aimed to investigate the relationship between circulating apoCIII levels and subclinical inflammation markers across different cohorts with distinctive inflammatory patterns: patients with metabolic disorders (MDs), patients with rheumatoid arthritis (RA), and controls. Specifically, we assessed the associations of apoCIII with acute inflammation biomarkers (e.
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- Rheumatoid arthritis (RA) is a chronic autoimmune disease linked to joint pain and disabilities, and ongoing research is examining its connection with cardiovascular (CV) disease.
- A study involving 219 RA patients, some with metabolic disorders, focused on measuring specific microRNAs and glycoproteins to understand their roles in inflammation related to RA and CV health.
- Findings revealed that RA patients had higher levels of glycoproteins compared to controls, which were correlated with inflammatory markers and certain miRNAs, suggesting that these glycoproteins may indicate RA severity and are related to both inflammation and CV disease.
Article Synopsis
- Rheumatoid arthritis (RA) is a chronic autoimmune disease that increases the risk of cardiovascular disease (CVD), and this study focused on evaluating new cardiovascular biomarkers in RA patients.
- Researchers assessed 199 RA patients for CVD risk factors, disease activity, and levels of biomarkers like fetuin-A and catestatin, finding significant correlations between these biomarkers and RA parameters.
- While elevated levels of catestatin and fetuin-A showed some associations with rheumatoid factor positivity and other disease markers, no significant links were found to traditional CVD measures like carotid intima-media thickness, indicating a need for more research on these biomarkers' roles in RA.
Article Synopsis
- The study examined the effectiveness and safety of Janus kinase inhibitors (JAKi) for treating rheumatoid arthritis-associated interstitial lung disease (RA-ILD), an area with limited therapeutic options.
- It included a systematic review of literature and meta-analysis of data from seven observational studies and found that JAKi improved lung function and imaging results in patients with RA-ILD.
- The results indicated that JAKi were generally well tolerated, with a low risk of developing new ILD, and showed similar safety and efficacy to existing treatments like abatacept and rituximab.
Introduction: Patients with RA are at a higher risk of developing CV diseases than the general population. The precise mechanisms are still unknown. We evaluated the associations between 8 plasma growth factors (GFs) (angiopoietin-2, EGF, HB-EGF, PLGF, TGF-α, VEGFa, VEGFc, and VEGFd) and subclinical arteriosclerosis in RA patients.
View Article and Find Full Text PDFBackground: The familial hypercholesterolemia (FH) diagnosis is based on clinical and genetic criteria. A relevant proportion of FH patients fulfilling the criteria for definite FH have negative genetic testing. Increasing the identification of true genetic-based FH is a clinical challenge.
View Article and Find Full Text PDFBackground: The diabetogenic effect of statins has been well established by clinical trials, Mendelian randomisation studies and meta-analyses. According to large clinical trials, PCSK9 inhibitors (PCSK9i) have no deleterious impact on glucose metabolism. However, few real-life studies have yet evaluated the long-term effects of these drugs on glucose homeostasis and their impact on new-onset diabetes (NODM).
View Article and Find Full Text PDFBackground And Aim: Triglyceride-rich lipoproteins (TRLs) can have an important role in atherosclerosis development due to their size and ability to penetrate the endothelium. While high plasma triglyceride (TG) levels and chronic inflammation are relevant in metabolic diseases, it remains unclear whether TGs are atherogenic or which TRL-TG-derived metabolites are responsible for inflammation. Here, we aimed to study the lipidome modifications of TRL particles enriched in TG in patients with hyperlipidemia and their associations with a proinflammatory status both in vivo and in vitro.
View Article and Find Full Text PDFRheumatoid arthritis (RA) is associated with problems beyond the joints such as cardiovascular (CV) disease. MicroRNA-24, -146 and -Let7a are associated with carotid plaque presence in RA patients. We evaluated whether these microRNAs were involved in the inflammatory state of RA, and we studied their gene targets to understand their role in inflammation and atherosclerosis.
View Article and Find Full Text PDFBackground And Aim: Circulating biomarkers of metabolic and cardiovascular diseases can help in the early detection and prevention of those diseases. Using proton nuclear magnetic resonance (1H-NMR), we aimed to study the plasma levels of low-molecular-weight metabolites (LMWMs) in a cohort of 307 patients with metabolic diseases to assess their relationships with type-2 diabetes (T2D) and incident atherosclerotic cardiovascular disease (ASCVD).
Methods: We conducted a cross-sectional and prospective study.
Objective: The search for new glucocorticoid-sparing disease-modifying anti-rheumatic drugs continues to be an unmet need in large vessel vasculitis (LVV). This report aims to assess the effectiveness and safety of leflunomide (LEF) in Takayasu arteritis (TA) and giant cell arteritis (GCA).
Methods: We systematically reviewed the literature, searching for studies evaluating the efficacy of LEF in LVV.
Article Synopsis
- Hypertension is linked to low-grade inflammation, with glycoproteins A, B, and F being potential indicators of this inflammatory state in affected patients.
- A study involving 340 patients (211 hypertensive and 129 normotensive) found that hypertensive individuals had higher levels of these glycoproteins, which correlated with increased blood pressure and prevalence of conditions like obesity and diabetes.
- The research suggests that elevated glycoproteins A, B, and F contribute to systemic inflammation, potentially leading to vascular injury and damage in other organs among hypertensive patients.
Article Synopsis
- Patients with rheumatoid arthritis (RA) have a higher risk of cardiovascular disease than the general population, and traditional risk factors don't fully account for this increased risk.
- A study involving 199 RA patients found that specific microRNAs in their plasma were linked to various markers of arterial health, like carotid intima-media thickness (cIMT) and the presence of carotid plaques.
- Key microRNAs, such as microRNA-24 and microRNA-146, may serve as potential predictors of cardiovascular risk in RA patients, highlighting their importance in understanding cardiovascular complications related to the disease.
Article Synopsis
- * The study utilized nuclear magnetic resonance (H-NMR) to analyze triglyceride-rich lipoproteins (TRLs) and acute-phase glycoprotein profiles in 280 patients, assessing their relationship with fatty liver disease through various liver function parameters.
- * Findings suggest that higher TRL particle concentrations and specific glycoprotein levels are positively associated with liver dysfunction and the future development of fatty liver, indicating these could serve as biomarkers for MAFLD in at-risk patients.
To validate in a cohort of 214 rheumatoid arthritis patients a panel of 10 plasmatic microRNAs, which we previously identified and that can facilitate earlier diagnosis of cardiovascular disease in rheumatoid arthritis patients. We identified 10 plasma miRs that were downregulated in male rheumatoid arthritis patients and in patients with acute myocardial infarction compared to controls suggesting that these microRNAs could be epigenetic biomarkers for cardiovascular disease in rheumatoid arthritis patients. Six of those microRNAs were validated in independent plasma samples from 214 rheumatoid arthritis patients and levels of expression were associated with surrogate markers of cardiovascular disease (carotid intima-media thickness, plaque formation, pulse wave velocity and distensibility) and with prior cardiovascular disease.
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