Controlled clinical trial comparing biaxial microincision with coaxial small incision for cataract surgery.

Purpose: Clinical outcomes of biaxial microincision versus coaxial small incision cataract surgery were compared in a prospective, controlled, paired-eye clinical study.

Methods: A total of 84 eyes of 42 patients underwent cataract surgery using the biaxial microincision (B-MICS) technique in either the right or left eye. The fellow eye was to undergo cataract surgery using the standard coaxial small incision (SICS) technique.

International Values of Central Pachymetry in Normal Subjects by Rotating Scheimpflug Camera.

Purpose: In corneal refractive surgery, postoperative ectasia risk assessment routinely includes pachymetric analysis at the apex and thinnest point. We examined whether these data differ worldwide and constructed preliminary country-specific normative thresholds.

Design: This was a multicenter, cross-sectional study.

Optimized constants for an ultraviolet light-adjustable intraocular lens.

Purpose: To determine the accuracy of intraocular lens (IOL) power calculations and to suggest adjusted constants for implantation of ultraviolet light-adjustable IOLs.

Setting: Center for Vision Science, Ruhr University Eye Clinic, Bochum, Germany.

Design: Cohort study.

Evaluation of corneal endothelial cell loss and corneal thickness after cataract removal with light-adjustable intraocular lens implantation: 12-month follow-up.

Purpose: To determine quantitative changes in endothelial cell loss and corneal thickness in patients having cataract surgery and implantation of a light-adjustable intraocular lens (IOL) to correct residual postoperative refractive errors by application of a spatially profiled near-ultraviolet (UV) light.

Setting: Ruhr University Eye Clinic, Bochum, Germany.

Design: Cohort study.

Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens.

Purpose: In an experimental autoimmune animal model, retinal ganglion cell (RGC) loss was induced through immunization with glaucoma-related antigens. The target of this study was to investigate the pathomechanism behind this decline and the serum antibody reactivity against ocular and neuronal tissues after immunization with glaucoma- and non-glaucoma-associated antigens.

Methods: Rats immunized with optic nerve antigen homogenate (ONA) or keratin (KER) were compared to control rats (CO).

Clinical evaluation of an ultraviolet light adjustable intraocular lens implanted after cataract removal: eighteen months follow-up.

Purpose: To determine the effectiveness of a light-adjustable intraocular lens (LAL) that can be adjusted postoperatively using ultraviolet (UV) irradiation.

Design: A prospective, nonrandomized clinical trial was conducted at Center for Vision Science, Ruhr University Eye Clinic, in Bochum, Germany.

Participants: We included 122 eyes of 91 patients with significant cataract.

International values of corneal elevation in normal subjects by rotating Scheimpflug camera.

Purpose: To examine whether clinically significant differences exist in corneal elevation data from a sampling of countries worldwide.

Setting: International multicenter.

Design: Evaluation of diagnostic test or technology.

Combined correction of axial hyperopia and astigmatism using the light adjustable intraocular lens.

Purpose: To determine whether residual spherical and cylindrical errors could be corrected postoperatively using spatially profiled UV light irradiation in patients with axial hyperopia undergoing cataract surgery and implantation of a light adjustable, silicone intraocular lens (LAL).

Design: We conducted a prospective, nonrandomized clinical trial. The LALs were implanted in eyes with axial lengths <22.

Combined correction of sphere and astigmatism using the light-adjustable intraocular lens in eyes with axial myopia.

Purpose: To determine the efficacy of light-adjustable intraocular lenses (IOL) in correcting residual spherical and cylindrical errors in patients with axial myopia.

Setting: Center for Vision Science, Ruhr University Eye Clinic, Bochum, Germany.

Design: Prospective cohort study.

In vitro susceptibility testing of meticillin-resistant and meticillin-susceptible staphylococci to mupirocin and novobiocin.

Antimicrobials effective against meticillin-resistant staphylococci are limited. Mupirocin is a topical antimicrobial used to treat bacterial skin infections. Novobiocin is an oral antimicrobial approved for treatment of staphylococcal upper respiratory infections in dogs.

Survival after transplantation of corneas from a rabies-infected donor.

Purpose: To examine the tissue samples of 2 corneal recipients from a rabies-infected donor for the presence of rabies to explain their survival.

Methods: Interventional case series with a review of the literature. The explanted corneal donor buttons were examined via nested reverse transcriptase polymerase chain reaction.

Evaluation of the Calhoun Vision UV Light Adjustable Lens implanted following cataract removal.

Purpose: To evaluate the effectiveness of a silicone intraocular lens (IOL) that can be adjusted following implantation using ultraviolet (UV) irradiation.

Methods: Prospective clinical trial of 40 patients (40 eyes) with visually significant cataract. Participants underwent small-incision phacoemulsification followed by implantation of a light-adjustable, silicone IOL (Light Adjustable Lens [LAL], Calhoun Vision).

Biaxial microincision versus coaxial small-incision cataract surgery in complicated cases.

Purpose: To evaluate and compare the results of biaxial microincision and coaxial small-incision surgery in patients with cataract with coexisting exfoliation syndrome, uveitis, anterior or posterior synechias, phacodonesis, or previous intraocular surgery over an 8-week follow-up.

Setting: Department of Ophthalmology, Mainz University, Mainz, Germany.

Methods: Eyes were prospectively assigned (1:1) to have biaxial microincision (<1.

Optical coherence tomography of macular thickness after biaxial vs coaxial microincision clear corneal cataract surgery.

Purpose: To evaluate macular thickness changes after biaxial microincision versus coaxial small incision cataract surgery using optical coherence tomography (OCT).

Methods: This prospective, randomized, marked study comprised 70 patients (70 eyes) undergoing biaxial microincision surgery or conventional coaxial phacoemulsification. Patients were evaluated by Stratus OCT preoperatively and 1 day, 4 weeks, and 8 weeks postoperatively.

Foldable Artiflex phakic intraocular lens for the correction of myopia: two-year follow-up results of a prospective European multicenter study.

Objective: To evaluate the safety, efficacy, predictability, stability, and complications of the foldable Artiflex iris-fixated intraocular lens (Ophtec BV, Groningen, The Netherlands) for the correction of myopia in phakic eyes.

Design: Prospective, nonrandomized, open-label, multicenter trial.

Participants: Two hundred ninety eyes of 191 patients aged 18 to 60 years with average spherical equivalent of -7.

[The light-adjustable lens. Principles and clinical application].

Despite improvements in preoperative lens power calculations many patients are in need of spectacle correction to achieve emmetropia and/or optimal distance vision after cataract surgery. A method to adjust residual spherical and astigmatic errors postoperatively in a predictable and non-invasive way is the implantation of the light-adjustable lens (LAL). Selective irradiation of the LAL with UV light (365 nm) using a digital light delivery device enables a customized light pattern for each patient which produces modifications in the lens curvature and lens power by polymerization of silicon monomers in the lens matrix.

Recent developments in aspheric intraocular lenses.

Purpose Of Review: Aspheric intraocular lenses (IOLs) were designed to improve functional vision on the assumption that reducing ocular spherical aberration would lead to improvements in contrast sensitivity. Although this has largely been confirmed by many studies, several recent studies have reported no difference in contrast sensitivity or in patient preference. The purpose of this article is to review recent findings and offer explanations for these apparently contradictory results.

Effect of trypan blue on the elasticity of the human anterior lens capsule.

Purpose: To evaluate the effect of trypan blue (VisionBlue) staining on the elastic properties of the human anterior lens capsule.

Setting: Center for Vision Science, Ruhr University Eye Hospital, Bochum, Germany.

Methods: Nineteen anterior capsules were obtained from 19 human eyes at the time of cataract operation.

New technology for sizing the continuous curvilinear capsulorhexis: prospective trial.

Purpose: To evaluate the deviation of the continuous curvilinear capsulorhexis (CCC) from the target size and shape when a data-injection ring is used.

Setting: University Eye Clinic, Bochum, Germany.

Methods: In a randomized clinical trial, the horizontal and vertical intraoperative and postoperative CCC diameters in 96 eyes having cataract surgery were measured and compared with a 5.

[Toric phakic intraocular lenses].

After more than 3 years of follow-up, the satisfactory results achieved with the toric iris-fixated phakic intraocular lens (IOL) mean we can regard implantation of this lens as a procedure with the potential to provide safe, predictable, effective and stable correction of astigmatic errors, providing patients are carefully selected and receive adequate preparation for surgery. The iris-fixated toric phakic IOL (Verisyse, Advanced Medical Optics; Artisan, Ophtec) is a PMMA lens with a total diameter of 8.5 mm and an optic diameter of 5 mm.

[Complications after laser in situ keratomileusis (LASIK): results of a meta-analysis on incidences and expectable costs].

Purpose: Laser in situ Keratomileusis (LASIK) is considered to be safe and effective for the treatment of moderate myopia. Nevertheless, the treatment can result in complications, associated with additional costs for treatment of the latter and an associated reduction of the primary treatment's overall cost efficiency.

Methods: To both identify clinically relevant LASIK-associated complications and to estimate their expectable incidence and treatment cost-profile, a quantitative meta-analysis of trial publications between 1995 - 2004 was implemented.

[Cataract surgery in childhood uveitis].

The development of cataract is the most frequent vision-threatening complication of uveitis in children. In such cases cataract surgery is associated with a particular risk of intra- and postoperative complications and requires an intensive perioperative immunosuppression, an essentially atraumatic operation in a quiscient eye, and aggressive amblyopia treatment. When these factors are taken into consideration, a timely cataract operation can result in a sustained visual rehabilitation even for children with uveitis.

Rheology of sodium hyaluronate saline solutions for ophthalmic use.

The aim of this work was to investigate the rheological properties of different saline solutions of sodium hyaluronate (NaHA) with special interest for medical applications. The experimental results were compared with literature data for commercial ophthalmic viscosurgical devices (OVDs) used in cataract surgery. We offer some tools to tailor the rheological behavior of OVDs for different purposes.

Endothelial cell loss after toric iris-fixated phakic intraocular lens implantation: three-year follow-up.

Purpose: To study quantitative changes in endothelial cell count after implantation of the toric iris-fixated phakic intraocular lens.

Methods: A prospective, non-randomized, self-controlled clinical trial was conducted of 40 eyes (28 myopic, 12 hyperopic) of 23 patients with high ametropia and astigmatism. Non-contact computer-assisted endothelial microscopy was performed before and 1, 2, and 3 years after surgery.