Publications by authors named "Dibb C"
Article Synopsis
- Venetoclax, when combined with azacytidine, shows promise in treating acute myeloid leukemia (AML), but some patients develop resistance, which can limit the treatment's effectiveness.
- Researchers tested 25 different drug combinations with venetoclax on AML patient samples to discover which combinations might work better than the standard venetoclax + azacytidine approach.
- By analyzing tumor cell states and incorporating clinical features, the study identified new drug combinations that could be more effective for certain patient subtypes, paving the way for personalized treatment strategies in AML.
Article Synopsis
- Interleukin-8 (IL-8) is an important signal that attracts immune cells called neutrophils and is produced by various cell types in response to inflammatory signals, particularly lipopolysaccharide (LPS).
- Normal bone marrow mononuclear cells primarily produce IL-8 in response to LPS, with its mRNA levels rising soon after stimulation and IL-8 protein levels increasing continuously over 72 hours.
- Compared to LPS, another cytokine called IL-1 beta is much less effective at inducing IL-8 production in bone marrow cells, although peripheral blood mononuclear cells respond strongly to IL-1 beta, suggesting bone marrow cells have a unique regulatory response to these signals.
The salient features of systemic or local inflammation are the myriad of cellular and humoral interactions that result in elicitation of inflammatory leukocytes. In this study using specialized connective tissue, intact whole blood, we demonstrate the gene expression of two novel chemotactic factors. The buffy-coat cellular expression of neutrophil chemotactic/activating factor/interleukin 8 (IL-8) and monocyte chemotactic/activating protein (MCP-1) mRNA were time and dose-dependent in response to either lipopolysaccharide or zymosan stimulation.
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