Assessing the article screening efficiency of artificial intelligence for Systematic Reviews.

Objectives: Artificial intelligence (AI) tools utilizing machine learning (ML) have gained increasing utility in medicine and academia as a means of enhancing efficiency. ASReview is one such AI program designed to streamline the systematic review process through the automated prioritization of relevant articles for screening. This study examined the screening efficiency of ASReview when conducting systematic reviews and the potential factors that could influence its efficiency.

The biological effects of Piezocision™ on bone for accelerated tooth movement: A systematic review of animal studies.

Objectives: This systematic review aimed to assess the biological response at tissue, cellular, and molecular levels following Piezocision™ surgery, and its efficacy in accelerating orthodontic tooth movement.

Material And Methods: A systematic review of the literature was conducted across 4 databases following the PRISMA guidelines up to May 2022. Prospective controlled animal studies involving healthy animals under active orthodontic treatment assisted by corticotomy performed with a piezotome (Piezocision™) published in the English language without time restrictions were included.

Optical Accuracy Assessment of Robotically Assisted Dental Implant Surgery for Partially Edentulous Patients: A Single-Arm Clinical Trial.

Purpose: To quantify the clinical accuracy of a robotically assisted implant guidance system in partially edentulous patients without the use of postoperative CBCT.

Materials And Methods: A total of 10 implants (7 patients) were placed in partially edentulous patients utilizing a robotically assisted implant guidance system. Following the implant placement, an intraoral scan was performed to register the implant position after attaching a scan body.

Artificial Intelligence Chatbots in Patient Communication: Current Possibilities.

ChatGPT, an artificial intelligence (AI) chatbot, can generate text prompts based on user input. This study investigated the possibility of utilizing this tool to generate adequate and relevant patient educational and management documents in the context of dental implant surgery. A total of 27 periodontists were surveyed on the accuracy and usefulness of AI-generated documents comprising informational handouts for patients on surgical risks and postoperative instruction sheets for dental implant placement in either smokers or patients with diabetes.

Robot assisted implant surgery: Hype or hope?

The 21st century is characterized by accelerated technological innovation, resulting in digitization of most areas of medicine and dentistry. Dental implant surgical planning has evolved from using analog static guides to computer generated guides and dynamic surgical guidance. Dynamic surgical placement has started gaining ground with the use of navigated surgery and robot assisted implant placement.

Piezocision Through Computer-Guided Navigation.

Numerous surgical techniques have been developed as effective means to facilitate orthodontic treatment, but they may cause significant postoperative discomfort. Piezocision was established as a flapless and minimally invasive technique to accelerate orthodontic tooth movement by com- bining small vertical incisions and piezoelectric corticotomies. Computed tomography is combined with the Piezocision technique to fabricate CAD/CAM surgical guides to prevent iatrogenic damage.

A hybrid technique for measurement of intra/extracellular proteins.

ELISA or Western blot is known as a basic technique to be used for measurement of intracellular proteins, but in some cases, they cannot overcome problems such as normalization between samples or extraneous costs for required commercial kits. In order to address this problem, we developed a rapid and effective method (a hybrid of Western blot and ELISA). We use this new hybrid method to detect and normalize trace protein changes in gene expression intracellularly at a lower cost.

Quantification and comparison of the regional acceleratory phenomenon in bone following piezosurgery or bur osteotomy: A pilot study in rats.

Background/objective: The Regional Acceleratory Phenomenon (RAP) can be induced surgically via decortication (selective cortical penetrations) of bone to accelerate orthodontic tooth movement. Few studies have compared the impact and efficiency of different decortication methods to induce the RAP. The aim of this study was to determine if there is a significant difference in the intensity of the RAP induced by a surgical defect created either using a piezoelectric knife or a rotary bur.

The pathogenic mechanism of oral bacteria and treatment with inhibitors.

Objectives: The objective of this study was to introduce the evidence obtained through extensive research that periodontitis increases risk of many systemic diseases.

Method: Analysis of some oral bacteria (P. gingivalis, T.

Assessment of Maxillary Expansion by Piezocision-Assisted Orthodontics: A Pilot Study.

The correction of transverse malocclusions due to maxillary width deficiency in adults is challenging. Multiple surgical and nonsurgical procedures have been used in conjunction with orthodontics to address this situation, and most common is the surgically assisted rapid maxillary expansion (SA-RME). Although successful, it is quite aggressive.

The role of TNF-α induced protein 1 in the activation of pro-apoptotic proteins.

It is known that Porphyromonas gingivalis/lipopolysaccharide (P. gingivalis/LPS) induces inflammatory diseases via TNF-α-mediated transcription factors. Our recent data shows that TNFAIP1 (TNF-α induced protein 1) is related to TNF-α.

Corticotomy depth and regional acceleratory phenomenon intensity.

Objectives: To determine if the depth of corticotomy done with the piezoelectric knife could play a role in the intensity of the regional acceleratory phenomenon (RAP).

Materials And Methods: Eighteen Sprague-Dawley rats were divided into two groups: untreated (3 rats) and treatment (15 rats). In the treatment group, a split-model design was used.

Strategic Use of Ultrasonic Frequencies for Targeted Bone Biomodification Following Piezoelectric Bone Surgery in Rats. Part II: Late Phase.

Piezoelectric surgery utilizes ultrasonic vibrations to cut bone more precisely and less traumatically than conventional methods. The regional acceleratory phenomenon following bone injury has a demineralization phase followed by a remineralization phase. Part I of this study on rats assessed the biologic modifications following bone injuries with the piezoelectric knife at 10-Hz and 30-Hz modulation frequencies.

Design and ex vivo characterization of narrow implants with custom piezo-activated osteotomy for patients with substantial bone loss.

Objective: Bone augmentation delays implant placement and increases risks due to additional surgeries. Implant systems compatible with reduced alveolar bone volume are required. To design, manufacture, and test a non-cylindrical dental implant system using piezotomes and custom-designed matching titanium mini-implants to address the needs of patients with missing teeth and narrow jawbone.

Cancer cells resist hyperthermia due to its obstructed activation of caspase 3.

Aim: It is well known that inducing hyperthermia is a type of cancer treatment but some research groups indicate that this treatment is not effective. This article finds and explains the mechanism of this treatment and its possible problems.

Background: Hyperthermia is commonly known as a state when the temperature of the body rises to a level that can threaten one's health.

Strategic Use of Ultrasonic Frequencies for Targeted Bone Biomodification Following Piezoelectric Bone Surgery in Rats. Part I: Early Phase.

Piezocision can set in motion a cascade of physiologic events that lead to accelerated orthodontics, but do all ultrasonic frequencies generate the same effects on bone? Two different Piezotome modulation frequencies (10 and 30 Hz) were tested on the rat maxilla. The animals were sacrificed at days 1, 3, 7, 14, 28, and 70, and MRI, histologic, and biochemical analyses were performed. The results indicated that at 30 Hz, the demineralization process started at day 1 and peaked at day 7, and was initiated by osteocyte apoptosis.

Retrospective study of the success of dental implants placed in HIV-positive patients.

Background: Data related to HIV-positive patients with dental implants is short-termed and limited. Recent data showed that both HIV and antiretroviral therapy (ART) could lead to low bone mineral density (BMD). The aim of this study was to determine the success rate of dental implants in HIV-positive patients.

A Randomized, Controlled, Multicenter Clinical Study Evaluating The Crestal Bone Level Change Of SLActive Bone Level Ø 3.3 mm Implants Compared To SLActive Bone Level Ø 4.1 mm Implants For Single-Tooth Replacement.

Purpose: The purpose of this prospective randomized clinical trial was to test the hypothesis that narrow-diameter titanium-zirconium (Ti-Zr) alloy implants with a chemically modified hydrophilic surface are not inferior in regard to crestal bone level change compared with standard-diameter implants with the same implant surface and material (control).

Materials And Methods: This multicenter study included 50 patients in need of a single tooth replacement in the anterior (canine to canine) or premolar region of the mandible or maxilla. Patients were included if the site could accommodate a 4.

Single-stage advanced versus rotated flaps in the treatment of gingival recessions: A 5-year longitudinal randomized clinical trial.

Background: The objective of the present study was to compare the efficacy of single-stage laterally positioned flap (LPF) and coronally advanced flap (CAF) techniques in the treatment of localized maxillary gingival recession (GR) defects, 1 and 5 years after surgical procedures.

Methods: Thirty-six patients with Miller Class I GR defects were randomly assigned to be treated by either CAF (n = 18) or LPF (n = 18). Recession height (RECH), width of keratinized tissue (WKT), probing depth (PD), vertical clinical attachment level (VAL), visual plaque score (VPS), and bleeding on probing (BOP) were assessed and compared.

A Clinical Investigation of the Efficacy of a Dual Zinc plus Arginine Dentifrice for Controlling Oral Malodor.

Objectives: The objective of this independent, double-blind clinical study was to assess the efficacy of a new Dual Zinc plus Arginine dentifrice (Colgate-Palmolive Co., New York, NY, USA) containing zinc (zinc oxide, zinc citrate) 0.96%, 1.

The involvement of Kav001 in inhibition of LPS/P. gingivalis-induced.

TNF-a is an important cytokine mediator of inflammation which suggests that inhibition of TNF activity may provide potential for clinical application. Recent data indicated that treatment of both human and mouse cells with Kavain significantly modulates P. gingivalis- and LPS-induced TNF-α expression.

A Pilot Study on the Efficacy of a Treatment Algorithm to Detoxify Dental Implant Surfaces Affected by Peri-implantitis.

This in vitro pilot study was performed to determine whether a treatment algorithm including mechanical debridement, followed by air powder abrasion with glycine, followed by citric acid conditioning with vigorous flushing of the surface with sterile water after each step, is capable of decontaminating an infected implant surface. A total of 14 dental implants that were deemed hopeless due to advanced peri-implantitis were extracted. Of these, 6 implants served as tests and had their exposed surfaces treated with the decontamination protocol, 6 served as untreated controls, and 2 were mechanically treated only, followed by rubbing the surface with sterile saline.

A method for high transfection efficiency in THP-1 suspension cells without PMA treatment.

Adherent cells such as mouse RAW cells or human cancer U2OS cells are beneficial to DNA transfection, with 20%-60% transfection efficiency. However, this DNA transfection is rarely used on suspension cells due to its low transfection efficiency (≤5%). We recently found a new DNA transfection method to increase the efficiency up to 13.

Bone microenvironment-mediated resistance of cancer cells to bisphosphonates and impact on bone osteocytes/stem cells.

Anti-resorptive bisphosphonates (BPs) have been clinically used to prevent cancer-bone metastasis and cancer-induced bone pathologies despite the fact that the phenotypic response of the cancer-bone interactions to BP exposure is "uncharted territory". This study offers unique insights into the interplay between cancer stem cells and osteocytes/osteoblasts and mesenchymal stem cells using a three-dimensional (3D) live cancer-bone interactive model. We provide extraordinary cryptic details of the biological events that occur as a result of alendronate (ALN) treatment using 3D live cancer-bone model systems under specific bone remodeling stages.