Effect of 2-Propanol on surface properties and wetting behavior of surfactants on the glass surface.

This study investigates the effects of 2-Propanol (2-PrOH) on the surface and wetting properties of anionic - Sodium bis(2-ethyl hexyl) sulfosuccinate, also known as Aerosol AT (AOT), Sodium Dodecyl Sulfate (SDS) - and cationic - Cetylpyridinium Chloride (CPC) and Cetyltrimethylammonium Bromide (CTAB) surfactants on a glass surface. Key surface properties including surface tension(), critical micelle concentration (CMC), surface excess concentration ( ), and minimum surface area per molecule ( ), were determined in water and varying parts by volume (0.10, 0.

Harnessing root phenotyping and root growth plasticity of landraces of maize ( L.) for enhancing waterlogging tolerance in fragile and challenging agro-ecologies of Eastern Himalaya.

Maize is a major crop of the Eastern Himalayan Region (EHR) which faces significant environmental challenges including waterlogging (WL) under changing climate. Through microcosm and field experiments, this study aimed to evaluate the phenotypic plasticity and adaptive mechanisms of maize landraces under WL conditions at the seedling and flowering stages. Based on the response coefficient and waterlogging tolerance coefficient 14 landraces at the seedling stage were found to be WL tolerant whereas RCM-12-19, RCM-32-19, and RCM-16-19, emerged as WL tolerant at both stages.

Morphological, ultrastructure and molecular characterization of (Acari: Hydrachnida: Unionicolidae) isolated from , West Bengal, India.

spp. is a parasitic aquatic mite known to infect freshwater aquatic organisms, especially the marine and freshwater molluscs and few species of sponges. (Acari: Hydrachnida: Unionicolidae) generally infect the freshwater bivalves of the Genus sp.

Understanding HLA-DQ in renal transplantation: a mini-review.

Human leukocyte antigen (HLA) mismatching, particularly with HLA-DQ, significantly impacts the development of donor-specific antibodies (DSA) and transplant outcomes. HLA-DQ antibodies are highly immunogenic and detrimental, necessitating advanced high-resolution HLA typing to improve mismatch assessment and clinical risk evaluation. Traditional serological or low-resolution typing often misclassifies mismatches, leading to inaccuracies in assessing immunogenicity and predicting outcomes.

ECG Signal Classification of Cardiovascular Disorder using CWT and DCNN.

Background: Cardiovascular Diseases (CVD) requires precise and efficient diagnostic tools. The manual analysis of Electrocardiograms (ECGs) is labor-intensive, necessitating the development of automated methods to enhance diagnostic accuracy and efficiency.

Objective: This research aimed to develop an automated ECG classification using Continuous Wavelet Transform (CWT) and Deep Convolutional Neural Network (DCNN), and transform 1D ECG signals into 2D spectrograms using CWT and train a DCNN to accurately detect abnormalities associated with CVD.

Loss of an uncharacterized mitochondrial methionine tRNA-synthetase induces mitochondrial unfolded protein response in .

Aminoacyl-tRNA synthetases (aaRSs) are essential for translation, as they charge tRNA molecules with their corresponding amino acids. Alterations in aaRSs can significantly disrupt both cytosolic and mitochondrial translation. Through a forward genetic screen for mitochondrial unfolded protein response (UPR) activators in , we identified a missense mutation (P447V) in the previously uncharacterized gene Y105E8A.

Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis.

Endothelial cells (ECs) lining blood vessels sense disturbed blood flow (D-flow), which drives mitochondrial dysfunction and atherosclerosis. Copper (Cu) is an essential micronutrient, and its disruption of homeostasis has been implicated in atherosclerosis. Cellular Cu levels are tightly controlled by Cu transport proteins including the Cu importer CTR1.

cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.

Approximately 50% of cancers exhibit decreased expression ( ), which is linked to immune checkpoint blockade (ICB) resistance. While is traditionally recognized as a tumor suppressor and cell cycle regulator, we have previously put forth a new paradigm demonstrating its role in intracellular metabolic reprogramming. Whether the metabolic derangement due to loss alters metabolites within the tumor microenvironment (TME) and how that affects the immune compartment and ICB response has never been investigated.

"Résorption radiculaire interne:" A case report on dual-phase management of extensive internal root resorption.

This case study delves into an uncommon occurrence of internal root resorption (IRR), an inflammatory variant with perforation of root, in the left central incisor, which seems to have a prevalence ranging from 0.01% to 1%. The patient presented with pain in the upper left front tooth, leading to a diagnosis of pulpal necrosis with symptomatic apical periodontitis.

The impact of SGLT-2 Inhibitors on the Risk of Atrial Fibrillation in Heart Failure.

Background: Heart failure (HF) and atrial fibrillation (AF) are closely linked, each exacerbating the other. While sodium-glucose cotransporter-2 inhibitors (SGLT2i) are known to provide substantial benefits in HF management, their effect on AF incidence in this population is not well-defined.

Objective: This study aims to assess the effect of SGLT2i therapy on the development of new-onset AF in patients with HF.

Dimethyl fumarate improves nuclear factor erythroid-related factor 2-mediated antioxidant response to ameliorate functional and molecular deficits in experimental diabetic neuropathy.

Objectives: In the present study, we tested the functional/pharmacological significance of dimethyl fumarate (DMF) in streptozotocin-induced diabetic neuropathy (DN) in rats and high glucose-exposed Neuro2a (N2a) cells.

Materials And Methods: To evaluate the pharmacological effects of DMF on diabetic neuropathy, we assessed behavioral and functional parameters of peripheral neuropathy, oxidative stress markers, and target protein expression using immunohistochemistry/immunocytochemistry, and Western blotting in diabetic rats and hyperglycemic N2a cells.

Results: Diabetic rats exhibited hyperalgesia, allodynia, and compromised sensory and motor nerve conduction velocities in comparison to normal rats.

Exact distributions of threshold crossing times of proteins under post-transcriptional regulation by small RNAs.

The timings of several cellular events like cell lysis, cell division, or pore formation in endosomes are regulated by the time taken for the relevant proteins to cross a threshold in number or concentration. Since protein synthesis is stochastic, the threshold crossing time is a first passage problem. The exact distributions of these first passage processes have been obtained recently for unregulated and autoregulated genes.

Theory of stochastic resonance with state-dependent diffusion.

Several interesting and important natural processes are the manifestation of the interplay of nonlinearity and fluctuations. Stochastic resonance is one such mechanism and is crucial to explain many physical, chemical, and biological processes, as well as having huge technological importance. The general setup to describe stochastic resonance considers two states.

Plasmodium blood stage development requires the chromatin remodeller Snf2L.

The complex life cycle of the malaria parasite Plasmodium falciparum involves several major differentiation stages, each requiring strict control of gene expression. Fundamental changes in chromatin structure and epigenetic modifications during life cycle progression suggest a central role for these mechanisms in regulating the transcriptional program of malaria parasite development. P.

A curated tissue-specific proteome, phosphoproteome, and kinome map of Drosophila melanogaster with an integrated outlook in circadian physiology.

The fruit fly Drosophila melanogaster is a simple multicellular model system widely used in biomedical research. Here, we aimed to curate a comprehensive tissue and organ-specific proteome, phosphoproteome, and kinome atlas of D. melanogaster.

Concurrent diphtheria and COVID-19 infection in an unvaccinated child.

We report the case of a girl in her middle childhood who presented with progressive neck swelling, sore throat, dysphagia, low-grade fever and malaise, and with no prior vaccinations. Examination revealed a 'bull neck' appearance with pseudomembranous pharyngitis, which showed bleeding on membrane removal. The patient did not have any respiratory distress, but RT-PCR confirmed the concurrent coinfection of DPT with SARS-CoV-2.

Variational Path Sampling of Rare Dynamical Events.

This article reviews the concepts and methods of variational path sampling. These methods allow computational studies of rare events in systems driven arbitrarily far from equilibrium. Based upon a statistical mechanics of trajectory space and leveraging the theory of large deviations, they provide a perspective from which dynamical phenomena can be studied with the same types of ensemble reweighting ideas that have been used for static equilibrium properties.

Cellulose-based biodegradable superabsorbent hydrogel: A sustainable approach for water conservation and plant growth in agriculture.

Innovative deficit irrigation technologies are imperative to overcome challenges posed to crop growth/yield and agriculture sustainability due to water scarcity in arid and semiarid regions. In the current study, superabsorbent biodegradable hydrogel based on carboxymethylcellulose sodium salt (NaCMC) and hydroxy ethyl cellulose (HEC) has been developed using citric acid (CA) as a crosslinker. The hydrogel has demonstrated excellent water absorption, retention, and release properties.

Common Mental health issues among non-refugee migrants in Australia: a scoping review.

Purpose: Mental health issues were the fourth leading cause of disease burden in Australia in 2022. About 30% of Australia's population are migrants, whose mental health is poorly understood. We aimed to report the prevalence and risk factors of common mental health issues among non-refugee migrants in Australia.

Impact of relative deprivation and ethnicity on the incidence rate of amyotrophic lateral sclerosis.

: This study assessed a sizable cohort of patients with amyotrophic lateral sclerosis (ALS) in a relatively deprived and ethnically diverse area in the northwest of England. We aimed to evaluate the interaction of relative deprivation and ethnicity with the incidence of ALS. : Six hundred and ninety-three adults from Greater Manchester who were diagnosed with ALS between 1 January 2011 and 31 December 2021 were included in this study.

Pervasive role of pruritus in impaired quality of life in patients with primary biliary cholangitis: Data from the GLIMMER study.

Background: Pruritus affects up to 80% of patients with primary biliary cholangitis (PBC) and reduces health-related quality of life (HRQoL). GLIMMER (NCT02966834) was a randomized, placebo-controlled phase IIb study of linerixibat in patients with PBC and pruritus. Using patient-reported outcome data from GLIMMER, we characterize the impact of pruritus in PBC.

Evaluation of male contraceptive efficacy of (L.) sw. in human and rat: an study.

The study focused on the spermicidal and anti-androgenic effects of aqueous-ethanolic (60:40) extract of Caesalpinia pulcherrima leaves (AEECPL) in human and rat samples from the viewpoint of its contraceptive efficacy through ex-vivo study. Six fertile adult males were selected randomly for semen collection. Parallelly sperm samples were collected by epididymal washing from six rats.

Knowledge, perception and attitude of dentists regarding the role of artificial intelligence in the field of pediatric dentistry: An online questionnaire study.

Background: Knowledge on the potential applications of artificial intelligence (AI) as a diagnostic instrument in the domain of pediatric dentistry is imperative, as AI may significantly influence present and future dental practice.

Objectives: The present study aimed to evaluate the knowledge, perception and attitude of pediatric dentists and postgraduate students in the pediatric specialty with regard to the employment of AI in pediatric dental practice.

Material And Methods: An online questionnaire survey was conducted among 375 participants (92 postgraduates, 203 faculty members and 80 private practitioners), who were provided with 19 closeended questions through the Google Forms link sent via email.