N-Heterocyclic Carbene vs. Thiophene - Chiral Adsorption and Unidirectional Rotation on Au(111).

N-Heterocyclic carbenes are highly effective ligands for anchoring functional organic molecules to metal surfaces and nanoparticles, facilitating the formation of self-assembled monolayers. However, their adsorption on surface is difficult to predict and control, and there is an ongoing debate on the geometry of NHC derivatives on gold surfaces and on the role of gold adatoms. We present two single molecules based on a benzimidazole NHC, one equipped with a thiophene substituent, and the other ending with a Br atom.

A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome.

: Rat sarcoma (Ras) proteins, Kirsten, Harvey, and Neuroblastoma rat sarcoma viral oncogene homolog (KRAS, HRAS, and NRAS, respectively), are a family of GTPases, which are key regulators of cellular growth, differentiation, and apoptosis through signal transduction pathways modulated by growth factors that have been recognized to be dysregulated in PCOS. This study explores Ras signaling proteins and growth factor-related proteins in polycystic ovary syndrome (PCOS). : In a well-validated PCOS database of 147 PCOS and 97 control women, plasma was batch analyzed using Somascan proteomic analysis for circulating KRas, Ras GTPase-activating protein-1 (RASA1), and 45 growth factor-related proteins.

and Gene Polymorphisms in Systemic Sclerosis.

The complex cytokine network plays an important role in disease susceptibility and development, therefore single-nucleotide polymorphisms (SNPs) in or near cytokine genes may be relevant to development of systemic sclerosis (SSc). We in this study investigated 22 SNPs in 13 cytokine genes of SSc patients, and their association with disease susceptibility. Twenty-three clinically diagnosed SSc patients were enrolled for this purpose along with 80 healthy volunteers for comparisons.

Detection of Oral Submucous Fibrosis at the Crossroads of Altering Nucleogeometry, Nuclear Spatial Distribution and Nuclear Molecular Abundance.

The manuscript concentrates on spatial distribution and various nucleomorphometric parameters of epithelium to diagnose Oral Submucous Fibrosis (OSF). Histologically confirmed OSF and normal submucosa tissue samples were procured and stained with diamidino phenylindole (DAPI) to visualize nuclei. E-cadherins and p63 were also immunohistochemically stained.

Exploring the potential anti-senescence effects of soybean-derived peptide Soymetide in mice hippocampal neurons via the Wnt/β-catenin pathway.

Soybean-based foods enhance cognitive functions by influencing hippocampal mechanisms. These salutary effects have so far been attributed to isoflavones present in soybeans. Considering cellular senescence contributes to cognitive decline and that no specific soy-derived peptides are known for their potential to mitigate senescence, we examined the efficacy of a thirteen amino acid soy-derived peptide, Soymetide, on a doxorubicin-induced senescence mice model.

Complex water networks visualized by cryogenic electron microscopy of RNA.

The stability and function of biomolecules are directly influenced by their myriad interactions with water. In this study, we investigated water through cryogenic electron microscopy (cryo-EM) on a highly solvated molecule, the Tetrahymena ribozyme, determined at 2.2 and 2.

Population-based Screening for Chronic Obstructive Pulmonary Disease Using the St. George's Respiratory Questionnaire in Resource-limited Settings.

Rationale: Spirometry, while necessary for the diagnosis of COPD, remains a scarce and costly resource worldwide. Screening questionnaires may help to bridge the diagnostic gap.

Objectives: We evaluated the performance of the St.

Compositionally Tuned Self-Activated Alkali Metal Vanadates for High Color Rendering White LEDs and IR Reflective Pigments.

Phosphor-converted white light-emitting diodes (pc-WLEDs) with a supreme color rendering index (CRI) remain challenging, particularly due to the limited accessibility of efficient cyan-green-emitting phosphors in the 480-520 nm emission range. Herein, a novel rare earth-free cyan-green-emitting Ta-substituted CsVO phosphor that exhibits a VO charge transfer enabled cyan-green emission band centered at ∼520 nm under the 370 nm near UV (n-UV) light is reported with an internal quantum efficiency of 93.9%.

Fabrication of Folic Acid-Derived Carbon Dot-Conjugated Chitosan Nanospheres as Theragnostic Agents for pH-Responsive Anticancer Drug Delivery.

The favorable success rate in cancer treatment predominantly depends on precise diagnosis with target-specific drug delivery, which can regulate the patient survival outcome rate. Moreover, proper tracking of the system's pH is very much crucial as most of the therapeutic's action and release rate depend on it. Therefore, this work has been intended to fabricate a folic acid-derived carbon dot (FACD) decorated with chitosan (Cs) in order to form nanospheres (FACD-Cs-Ns) for anticancer doxorubicin hydrochloride (Dox.

MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance.

MicroRNAs (miRNAs) are a class of small non-coding RNAs which are associated with post-transcriptional regulation of gene expression. Dysfunction or aberrant expression of miRNAs is predominant in various malignancies including lung cancer. Lung cancer is one of the commonest causes of cancer-related death worldwide, with a five-year survival of only 10-20%.

Understanding the Therapeutic Potential of Smilax perfoliata and Elsholtzia griffithii Through GC-MS Analysis, Antimicrobial Assay and Molecular Docking.

Herbalism, rooted in traditional knowledge and regional practices, leverages plants as medicinal resources. India, with its vast biodiversity, harbors numerous untapped medicinal plants. This study focuses on the bioprospecting of two underexplored wild medicinal plants, Elsholtzia griffithii from Manipur and Smilax perfoliata from West Bengal, aiming to document their medicinal potential.

Effect of Desmopressin in Post Kidney Biopsy Bleeding Complication in Patients with Reduced Renal Function: A Randomized Controlled Trial.

Background: Bleeding complications after kidney biopsy in patients with reduced renal function concern renal physician. We designed this study to examine the impact of desmopressin on reducing bleeding complications at 6 and 24 hours post-procedure in patients with eGFR≤60ml/min/1.73m2.

Giant Polyoxometalate {W72Fe30} into Pure Inorganic Gel and Xerogel: Rheology and Proton Conduction.

Polyoxometalate (POM) gel is well-known but mostly with organic molecules.  Pure inorganic POM gel, i.e.

PPh3/Isocyanide and N2/Isocyanide Exchange: Pathways to Isolable Alkali Metal Keteniminyl Anions.

Keteniminyl anions hold significant promise for advancing ketenimine chemistry, yet their isolation has remained elusive until now. Drawing inspiration from recent advances in ligand exchange reactions at carbon, we report the successful synthesis of isolable alkali metal keteniminyl anions through substitution of the phosphine ligand in metalated ylides or the N2 ligand in a diazomethanides with isocyanides. The exchange reactions were found to proceed more rapidly with aryl isocyanides than with the more electron-rich alkyl-substituted derivatives and were also more efficient when starting from the diazo compounds.

Plasmodium falciparum histidine-rich protein 2/3 gene deletions and repeat motifs in Chhattisgarh, India (2017-2018).

Background: Rapid diagnostic tests (RDTs) are vital for malaria diagnosis, especially in resource-limited areas. RDTs targeting histidine-rich protein 2 (PfHRP2) and its structural homologue PfHRP3 are commonly used for detecting Plasmodium falciparum. However, genetic deletions in these proteins can affect test accuracy.

Precision in Midst of Crisis: Rigid Bronchoscopy in Management of Intrapulmonary Hemorrhage.

Rarely we encountered massive intra-pulmonary hemorrhage in clinical practice, which is always considered a life-threatening condition. In this case report we will discuss its management with removing blood clots using a rigid bronchoscope. Moreover, we also discuss about innovation, using a flexible fibre-optic bronchoscope through the rigid bronchoscope and removing a huge blood clot from terminal bronchioles.

Laryngeal Neuroendocrine Carcinoma.

Introduction: Neuroendocrine tumours of the larynx are extremely rare, though they make up only 1% of tumours in this region with the most common site being the supraglottis. On exhaustive research on PubMed, there are only a few prior cases of neuroendocrine carcinoma of subglottis published in the literature.

Case Report: A 56-year-old male presented to our center with complaints of hoarseness and dyspnoea for 1 month which was insidious in onset and gradually progressive.

Ignition of non-equilibrium methane dielectric barrier discharges in a multiphase plasma-liquid microfluidic device.

Atmospheric pressure plasma conversion of methane is usually addressed in gas-only systems, such as dry reforming of methane. Introducing a liquid in such a system enables direct utilization of plasma-produced radicals, such as methyl (CH), as a reactant in the liquid. Methylation of organic liquids by this technique can lead to the sustainable production of high-value products.

Ionic Liquid-Induced Modulation of Ubiquitin Stability: The Dominant Role of Hydrophobic Interactions.

Despite the widespread use of imidazolium-based ionic liquids (ILs) in biotechnology, pharmaceuticals, and green chemistry, their detailed interactions with proteins, particularly affecting structural stability, remain poorly understood. This study examines the effects of ILs on ubiquitin, a thermodynamically robust protein with a β-grasp structure. We found that IL-induced destabilization follows a consistent order with previous findings: [BMIM] > [BMPyr] > [EMIM] for cations and [BF] > [MeSO] > [Cl] for anions.

Enzyme-activating B-cell receptors boost antigen presentation to pathogenic T cells in gluten-sensitive autoimmunity.

Autoantibodies against the enzyme transglutaminase 3 (TG3) are characteristic to the gluten-sensitive skin disorder dermatitis herpetiformis (DH), which is an extraintestinal manifestation of celiac disease. We here demonstrate that TG3-specific B cells can activate gluten-specific CD4 T cells through B-cell receptor (BCR)-mediated internalization of TG3-gluten enzyme-substrate complexes. Stereotypic anti-TG3 antibodies using IGHV2-5/IGKV4-1 gene segments enhance the catalytic activity of TG3, and this effect translates into increased gluten presentation to T cells when such antibodies are expressed as BCRs.

Graph-structured populations elucidate the role of deleterious mutations in long-term evolution.

Birth-death models are used to understand the interplay of genetic drift and natural selection. While well-mixed populations remain unaffected by the order of birth and death and where selection acts, evolutionary outcomes in spatially structured populations are affected by these choices. We show that the choice of individual moving to vacant sites-parent or offspring-controls the initial mutant placement on a graph and hence alters its fixation probability.