Publications by authors named "Diaz-Gomez J"

Background: self-efficacy in breastfeeding influences the duration of breastfeeding. There is a validated scale to measure it, the Breastfeeding Self Efficacy Scale-Short Form (BSES-SF), developed by Dennis et al. AIMS: to examine the internal structure of the BSES-SF, verify if the score changes in the first months of lactation and if it is related to early cessation of breastfeeding.

View Article and Find Full Text PDF
Article Synopsis
  • The study explores how the PD-1 immune checkpoint protein is regulated on CD8 T cells, aiming to find ways to lower its abundance without hindering T cell activation, which is crucial for effective cancer therapy.
  • Researchers conducted a CRISPR-Cas9 screen on murine CD8 T cells to identify genes impacting PD-1 levels, discovering that inhibiting the TMED protein family, especially TMED10, could reduce PD-1 on the cell surface and enhance T cell function.
  • The findings highlight a new regulatory mechanism for PD-1 and suggest that targeting TMED could be a promising therapeutic strategy to improve T cell responses in cancer treatment, as indicated by correlations in mouse models and patient survival data.
View Article and Find Full Text PDF

Point-of-care ultrasound (POCUS) involves the acquisition, interpretation, and immediate clinical integration of ultrasonographic imaging performed by a treating clinician. The current state of cardiac POCUS terminology is heterogeneous and ambiguous, in part because it evolved through siloed specialty practices. In particular, the medical literature and colloquial medical conversation contain a wide variety of terms that equate to cardiac POCUS.

View Article and Find Full Text PDF

Purpose: Despite the potential value of point-of-care ultrasonography (POCUS) in resource-limited environments, it is not widely used in low- and middle-income countries compared with high-income countries. We sought to evaluate the current POCUS practice of Ukrainian anesthesiologists who attended POCUS courses to guide future POCUS training in Ukraine.

Methods: We conducted a 25-question web-based survey.

View Article and Find Full Text PDF

Objectives: Clinical practice guidelines are essential for promoting evidence-based healthcare. While diversification of panel members can reduce disparities in care, processes for panel selection lack transparency. We aim to share our approach in forming a diverse expert panel for the updated Adult Critical Care Ultrasound Guidelines.

View Article and Find Full Text PDF

Genes limiting T cell antitumor activity may serve as therapeutic targets. It has not been systematically studied whether there are regulators that uniquely or broadly contribute to T cell fitness. We perform genome-scale CRISPR-Cas9 knockout screens in primary CD8 T cells to uncover genes negatively impacting fitness upon three modes of stimulation: (1) intense, triggering activation-induced cell death (AICD); (2) acute, triggering expansion; (3) chronic, causing dysfunction.

View Article and Find Full Text PDF

Development of therapeutic agents that have fewer adverse effects and have higher efficacy for diseases, such as cancer, metabolic disorders, neurological diseases, infections, cardiovascular diseases, and respiratory diseases, are required. Recent studies have focused on identifying novel sources for pharmaceutical molecules to develop therapies against these diseases. Among the sources for potentially new therapies, animal venom-derived molecules have generated much interest.

View Article and Find Full Text PDF

To assess point-of-care ultrasound (POCUS) in 2024, we should start by defining its expanded scope and integration into general and specialty practice. Clinicians should abide by the evolving evidence for POCUS utilization and patient outcomes different from mortality and morbidity, especially as there are notable advancements in handheld ultrasound technology with a clear shift from capability to portability. To reduce diagnostic errors, POCUS practitioners need a holistic framework that accounts for known and new applications.

View Article and Find Full Text PDF

Point of care ultrasound has become an integral part of critical care medicine, particularly for recognizing shock etiologies and guiding management. Most of the current ultrasonography guided shock protocols have been tailored towards a qualitative assessment of patients on presentation with shock. Unfortunately, the evolving nature of shock, particularly in the face of resuscitation and physiologic changes, demands a more sophisticated approach.

View Article and Find Full Text PDF

This report highlights survival and the patient's perspective after prolonged venovenous extracorporeal membrane oxygenation (ECMO) for COVID-19-related respiratory failure. A 36-year-old man with COVID-19 presented with fever, anosmia, and hypoxia. After respiratory deterioration necessitating intubation and lung-protective ventilation, he was referred for ECMO.

View Article and Find Full Text PDF

The clinical approach to undifferentiated shock in critically ill patients should be revised to use modern, point-of-care tools that are readily available. With the increasing availability of 2-dimensional ultrasonography and advanced Doppler capabilities, a quick, simplified, and integrated stepwise approach to shock using critical care echocardiography is proposed. Evidence supports the feasibility and usefulness of critical care echo-cardiography in enhancing diagnostic accuracy for shock, but there is a lack of systematic application of the technology in patients with undifferentiated shock.

View Article and Find Full Text PDF

The application of natural coagulants derived from food byproducts in domestic wastewater tertiary treatment, which contains a number of impurities as suspended colloidal particles, has a potential use as essential substitutes for traditional inorganic coagulants. These biomaterials are a sustainable and environmentally friendly alternative that can be used to improve water quality and human health. In this study, prickly pear (PP) fruit peel mucilage gel was evaluated as a novel coagulant for the tertiary stage of domestic wastewater treatment.

View Article and Find Full Text PDF

Objectives: A number of trials related to critical care pharmacotherapy were published in 2022. We aimed to summarize the most influential publications related to the pharmacotherapeutic care of critically ill patients in 2022.

Data Sources: PubMed/Medical Literature Analysis and Retrieval System Online and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update.

View Article and Find Full Text PDF

Streptococcus gallolyticus (SG) is a Gram-positive cocci found as commensal gut flora in animals and humans. SG has emerged as a cause of disease in young poults between 1 and 3 wk of age. SG is associated with septicemia resulting in acute mortality with no premonitory signs in turkeys.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers are studying immune cells called tumor infiltrating lymphocytes (TILs) in endometrial cancer (EC) to see how they affect the disease.
  • They analyzed TILs from 47 tumors to understand their characteristics and how well they recognize and respond to cancer cells.
  • The results showed that certain TILs with specific markers (like PD-1 and CD39) are better at fighting the cancer and their presence might relate to patient survival and the tumor's characteristics.
View Article and Find Full Text PDF

Studies that specifically quantify the appropriateness of the process of dialysis modality selection are lacking. Peritoneal dialysis (PD) offers clinical and social advantages over hemodialysis (HD), but may be underused. We aimed to determine the appropriateness of the process of dialysis modality selection and quantify the percentage of patients who could potentially have been PD candidates.

View Article and Find Full Text PDF

• Echocardiography and CMR are used for diagnosis of HCM. • Learning echocardiography requires advanced and repetitive training. • A 3D model can enhance understanding of cardiac anatomy and pathophysiology.

View Article and Find Full Text PDF

Gender violence is a major public health issue. The aim of this study was to determine the prevalence of sexist attitudes that could be associated with said violence, and to identify some sociodemographic variables that predict sexism. A cross-sectional observational study was conducted with 723 adolescents between the ages of 14 to 19.

View Article and Find Full Text PDF

Patients with severe refractory hypoxemic respiratory failure may benefit from extracorporeal membrane oxygenation (ECMO) for salvage therapy. The Coronavirus disease 2019 (COVID-19) pandemic offered three high-volume independent ECMO programs at a large medical center the chance to collaborate to optimize ECMO care at the beginning of the pandemic in Spring 2020. Between March 15, 2020, and May 30, 2020, 3,615 inpatients with COVID-19 were treated at the Texas Medical Center.

View Article and Find Full Text PDF