Publications by authors named "Dianwu Li"
Residential greenness, air pollution, genetic predisposition and the risk of lung cancer.
Ecotoxicol Environ Saf
March 2025
Background: Growing evidence suggests that greenness is associated with multiple health outcomes, but its association with lung cancer risk remains limited and far from consistent. In particular, it is unclear whether this association varies across different types of lung cancer and whether it is influenced by factors such as genetics, air pollution, and physical activity.
Method: This prospective cohort study included 425108 participants aged 37-73 years from the UK Biobank.
SEC14L2 regulates the transport of cholesterol in non-small cell lung cancer through SCARB1.
Lipids Health Dis
December 2024
Background: Inhibiting cholesterol metabolism has shown great potential in non-small cell lung cancer (NSCLC). However, the regulatory mechanism of the lipid metabolism key factor Sect. 14-like lipid binding 2 (SEC14L2) in NSCLC remains unclear.
View Article and Find Full Text PDFBackground And Objectives: Telomere length (TL) has been acknowledged as biomarker of biological aging. Numerous investigations have examined associations between individual early life factors and leukocyte TL; however, the findings were far from consistent.
Research Design And Methods: We evaluated the relationship between individual and combined early life factors and leukocytes TL in middle and late life using data from the UK Biobank.
Background: Sedentary behavior (SB) has emerged as a significant health concern that deserves attention. This study aimed to examine the associations between prolonged sedentary behavior and the risk of all-cause and cause-specific mortality as well as to explore desirable alternatives to sitting in terms of physical activity (PA).
Methods: Two prospective cohort investigations were conducted using the UK Biobank and NHANES datasets, with a total of 490,659 and 33,534 participants, respectively.
Background: Health problems associated with shift work and night shift work are gaining increasing public attention.
Objective: To investigate the association between night shift work and the hazard of mortality.
Design: Prospective cohort study.
Background: Although it is widely acknowledged that long-term exposure to ambient air pollution is closely related to the risk of mortality, there were inconsistencies in terms of cause-specific mortality and it is still unknown whether lifestyle and genetic susceptibility could modify the association.
Methods: This population-based prospective cohort study involved 461,112 participants from the UK Biobank. The land-use regression model was used to estimate the concentrations of particulate matter (PM, PM, PM), and nitrogen oxides (NO and NO).
Background: Several characteristics distinguish lung cancer in female patients from that in male patients, with adenocarcinoma being more prevalent in female patients and occurring more frequently in female patients who do not smoke. Uncertainty surrounds the relationship between female-specific reproductive factors and lung cancer risk.
Research Question: Are sex-specific reproductive factors associated with risk of lung cancer in different genetic risk groups and histologic types?
Study Design And Methods: A Cox proportional hazard model was used to evaluate the association between multiple reproductive factors and the risk of lung cancer developing in a prospective cohort study involving 273,190 female individuals from the UK Biobank.
Introduction: Vitamin D has been known to be associated with asthma, particularly in children, while the evidence among adults is limited and inconclusive. This study aimed to investigate the association between serum, vitamin D concentrations, and the incidence of adult-onset asthma and also the modified effect caused by sleep patterns and genetic risks.
Methods: A prospective cohort study with 307,872 participants aged between 37 and 73 years was conducted based on the UK Biobank, with a median follow-up of 12 years.
Background: Numerous studies have explored the association of air pollution with asthma but have yielded conflicting results. The exact role of air pollution in the incidence of adult-onset asthma and whether this effect is modified by genetic risk, lifestyle, or their interaction remain uncertain.
Methods: We conducted a prospective cohort study on 298,738 participants (aged 37-73 years) registered in the UK Biobank.
Background: Both genetic and lifestyle factors contribute to the development of asthma, but whether unfavourable lifestyle is associated with similar increases in risk of developing asthma among individuals with varying genetic risk levels remains unknown.
Methods: A healthy lifestyle score was constructed using body mass index, smoking status, physical activities and dietary pattern to further categorise into ideal, intermediate and poor groups. Genetic risk of asthma was also categorised as three groups based on the tertiles of polygenic risk score established using 212 reported and verified single-nucleotide polymorphisms of European ancestry in the UK Biobank study.
Background: Multiple studies showed sex discrepancies in the prevalence, incidence, and disease control of asthma. The relationships between different reproductive factors and the risk of asthma in females remain uncertain.
Design: A prospective cohort study recruited 239,701 female participants from the UK Biobank.
Objectives: The effect of air pollution exposure on incident lung cancer remains uncertain, and the modifying role of lifestyle and genetic susceptibility in association between air pollution and lung cancer is ambiguous.
Methods: A total of 367,623 participants from UK biobank cohort were enrolled in the analysis. The concentrations of particle matter (PM, PM), nitrogen dioxide (NO), and nitrogen oxides (NO), were evaluated by land-use regression model.
Article Synopsis
- Leptospirosis, a disease caused by pathogenic spirochetes from the genus Leptospira, lacks a standardized definition and diagnostic criteria for its severe forms, highlighting the need for deeper understanding of its clinical aspects.
- A study analyzed 95 patients to identify distinct clinical types of leptospirosis using methods like multiple correspondence analysis, revealing three types: mild, respiratory, and hepato-renal leptospirosis, each with varying symptoms, hospital stays, and outcomes.
- Key findings indicated a 15.8% mortality rate linked to dyspnea and elevated neutrophil levels, suggesting these factors could help predict severe cases of the disease.
Background: Previous observational studies investigated the relationship between coffee and tea intake and the risk of asthma, however, the conclusions were inconsistent. Further, the combined effect of coffee and tea consumption on asthma has rarely been studied. Methods: We examined associations between the self-reported intake of tea and coffee and the risk of incident asthma in a total of 424,725 participants aged from 39 to 73 years old from the UK Biobank.
View Article and Find Full Text PDFBackground: Vitamin D has been known to be associated with asthma. However, the association between vitamin D status and asthma, lung function as well as hospitalization among adults remains unclear.
Objective: To investigate the role of serum vitamin D in asthma prevalence, lung function, and asthma control in adults.
Objective: (TM) is an opportunistic fungus that is predominantly prevalent among patients who are HIV-positive in South-East Asia. However, few studies focused on the clinical features, laboratory findings, and prognosis across varying immune states.
Methods: A total of 54 patients with TM infection in Xiangya Hospital of Central South University from January 1, 2006 to October 31, 2021 were retrospectively analyzed.