KIF18B as a regulator in microtubule movement accelerates tumor progression and triggers poor outcome in lung adenocarcinoma.

KIF18B is involved in several tumor progression and exerts critical effects on microtubule growth during mitosis, but its role in lung adenocarcinoma still remains rare. Hence, we attempted to explore the biological function of KIF18B in lung adenocarcinoma. We first analyzed the expressional pattern of KIF18B in lung adenocarcinoma, and detected the correlation between KIF18B expression and clinical characteristics in lung adenocarcinoma based on The Cancer Genome Atlas (TCGA) database and Oncomine dataset.

[A cross-sectional survey of familial aggregation of chronic obstructive pulmonary disease: in seven provinces/cities in China].

Objective: To investigate the familial aggregation in chronic obstructive pulmonary disease (COPD).

Methods: Based on a cross-sectional survey in seven provinces/cities in China (Beijing, Shanghai, Guangdong, Liaoning, Tianjin, Chongqing and Shaanxi) from 2002 to 2004, the familial aggregation of COPD was investigated with multi-stage cluster random sampling method.One urban and one rural area were selected as samples from each of seven provinces/cities.

[The prevalence and risk factors of bronchiectasis in residents aged 40 years old and above in seven cities in China].

Objective: To investigate the prevalence and risk factors of bronchiectasis in urban city of China.

Methods: A cross-sectional survey was conducted in 17 urban areas in Beijing, Shanghai, Tianjin, Chongqing cities, and Guangdong, Liaoning, Shanxi provinces. In this study, urban population-based cluster samples were randomly selected from each city/province.

Asymptomatic patients of chronic obstructive pulmonary disease in China.

Background: Chronic obstructive pulmonary disease (COPD) has a variable natural history and not all individuals follow the same course. This study aimed to identify the prevalence and characteristics of asymptomatic COPD patients from a population-based survey in China.

Methods: A multistage cluster sampling strategy was used in a population from seven different provinces/cities.

Chronic obstructive pulmonary disease in the absence of chronic bronchitis in China.

Background And Objective: COPD has a variable natural history and not all individuals follow the same course. The aim of this study was to assess the prevalence of COPD in the absence of chronic bronchitis (CB) based on a population survey in China, and to identify the determinants of CB in patients with COPD.

Methods: A multi-stage cluster sampling strategy was used to survey a population from seven different provinces/cities of China.

[Current status of prevention and management of chronic obstructive pulmonary disease in rural area in China].

Objective: To investigate the current status of prevalence, prevention and management of chronic obstructive pulmonary disease (COPD) in rural area in China.

Methods: A cross-sectional survey of COPD was conducted in Beijing city, Shanghai city, Guangdong province, Liaoning province, Tianjin city, Chongqing province and Shanxi province. A population-based cluster sample was randomly selected from each rural area.

[The quality of life of patients with chronic obstructive pulmonary disease and correlated factors].

Objective: To evaluate the quality of life (QOL) of patients with chronic obstructive pulmonary disease (COPD) and correlated factors.

Methods: Data of 20 245 patients with COPD were collected from the cross-sectional survey of COPD, which was conducted between 2002 and 2004 in urban and rural areas of Beijing, Shanghai, Guangdong, Liaoning, Tianjin, Chongqing and Shanxi for residents aged over 40 years old. The recruited populations were interviewed with questionnaire and tested for spirometry.

Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey.

Rationale: The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown.

Objectives: To obtain the COPD prevalence in China through a large-population, spirometry-based, cross-sectional survey of COPD.

Methods: Urban and rural population-based cluster samples were randomly selected from seven provinces/cities.

[The risk factors for chronic obstructive pulmonary disease in females in Chinese rural areas].

Objective: To explore the risk factors for chronic obstructive pulmonary disease (COPD) in females in Chinese rural areas.

Methods: Based on a national multi-center, population-based and cross-sectional survey on prevalence of COPD in seven provinces/cities of China, an analysis on the risk factors for the rural females was conducted in six areas, e.g.

[A study on the correlation of body mass index with chronic obstructive pulmonary disease and quality of life].

Objective: To investigate the correlation between body mass index (BMI) and chronic obstructive pulmonary disease (COPD), based on a cross-sectional COPD survey conducted in Beijing, Shanghai, Guangdong, Liaoning, Tianjin, Chongqing and Shaanxi of China between 2002-2004.

Methods: A multi-stage stratification cluster sampling strategy was used in this cross-sectional survey, and 20,245 subjects (8705 males and 11,540 females) aged 40 years or older were recruited, interviewed with a questionnaire, measured for height and weight, and tested with spirometry. 1668 subjects with post-bronchodilator FEV1/FVC less than 70% were identified as having COPD after other known causes of airflow limitation were excluded.

[Purification and characterization of the fusion protein TGF-betaR II/Fc].

Aim: To express the fusion protein TGF-betaR II/Fc in large amounts by using recombinant Bac-TR II baculovirus expression system constructed by our laboratory and to purify and characterize it. Then, to verify whether the fusion protein TGF-betaR II/Fc can be able to block the biological activity of cytokine TGF-beta1.

Methods: The viral titer was determined by plaque forming test.

[Effects and mechanisms of fibronectin on adhesion and migration of different types of lung cancer cell lines].

Background: To observe and explore the effects and mechanisms of fibronectin (FN) on invasion of different types of lung cancers.

Methods: Using tumor invasion models in vitro of plates coated with FN and Boyden chambers with FN filter, differences of adhesion and migration between small cell lung cancer cell line (054A) and adenocarcinoma cell line (A549) were investigated, and proliferative effects of FN on cells were examined. In the meantime the invasive capability changes were observed after cell suspensions were preincubated with anti-α5, anti-α3 and anti-β1 integrin antibodies, respectively.

[Cost analysis of Shenqi Fuzheng injection on reducing adverse effects during chemotherapy].

Objective: The goals of this work was to analyse the cost of Shenqi Fuzheng injection-an extraction of a Chinese traditional herbs on reducing adverse effects in lung cancer patients during chemotherapy.

Methods: In a randomized cross-over trial, each patient completed two identical cisplatin-based chemotherapy cycles, one with Shenqi Fuzheng injection, another without Shenqi Fuzheng injection. Adverse effects and change scores of quality of life (QOL) during chemotherapy were compared in tow cycles.