Publications by authors named "Dianne Y Yap"
Article Synopsis
- Scientists studied how the bacteria found in Aedes aegypti mosquito larvae can affect how easily the mosquitoes get sick from viruses like Zika.
- They discovered that the type of bacteria and the genetics of the mosquitoes are important in deciding how many of them get infected.
- Understanding this relationship helps us figure out how to stop these mosquitoes from spreading diseases, especially as they move to new places because of climate change.
Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients. Cytosine-to-thymine (C-to-T) transition mutations (C250T or C228T) in the promoter create binding sites for transcription factors, which enhance transcription. The G-rich strand of the promoter can form G-quadruplex structures, whereas the C-rich strand can form an i-motif in which multiple cytosine residues are protonated.
View Article and Find Full Text PDFDetection of donor-specific anti-HLA antibodies (DSA) has been associated with graft rejection in all forms of transplantation. The mechanism by which DSA increase the risk of graft failure remains unclear. We hypothesized that complement-binding DSA are associated with engraftment failure in hematopoietic stem cell transplantation (HSCT) and analyzed 122 haploidentical transplant recipients tested prospectively for DSA.
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