An exploration of pediatric nurses' compliance with a medication checking and administration protocol.

Purpose: This study examined nurses' reported compliance with the medication administration protocol and explored reasons for noncompliance.

Design And Method: A mixed-methods design incorporated a questionnaire (n= 72) and focus groups (n= 24).

Results: Differences were found between the level of experience and protocol compliance.

The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development.

Poly(ADP-ribose) polymerase (PARP) is a major NAD-dependent modifying enzyme that mediates important steps in DNA repair, transcription, and apoptosis, but its role during development is poorly understood. We found that a single Drosophila Parp gene spans more than 150 kb of transposon-rich centromeric heterochromatin and produces several differentially spliced transcripts, including a novel isoform, PARP-e, predicted to encode a protein lacking enzymatic activity. An insertion mutation near the upstream promoter for Parp-e disrupts all Parp expression.